Detailed information of TA system TA168106

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3391828..3392469
• Replicon: chromosome
• Accession: NZ_CP059041
• Organism: Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1E3M967
• Locus tag: H0N28_RS16030
• Protein ID: WP_009518132.1
• Coordinates: 3391828..3392217 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: H0N28_RS16035
• Protein ID: WP_011860336.1
• Coordinates: 3392224..3392469 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0N28_RS16015	3386945..3389140	-	2196	WP_001158904.1	TRAP transporter large permease subunit	-
H0N28_RS16020	3389328..3389894	-	567	WP_000651535.1	rhombosortase	-
H0N28_RS16025	3389973..3391058	-	1086	WP_000049106.1	hypothetical protein	-
H0N28_RS16030	3391828..3392217	-	390	WP_009518132.1	hypothetical protein	Toxin
H0N28_RS16035	3392224..3392469	-	246	WP_011860336.1	succinate dehydrogenase assembly factor 2	Antitoxin
H0N28_RS16040	3392669..3393841	+	1173	WP_001190550.1	acyl-CoA dehydrogenase family protein	-
H0N28_RS16045	3393890..3395380	-	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
H0N28_RS16050	3395562..3395939	-	378	WP_001216380.1	50S ribosomal protein L17	-
H0N28_RS16055	3395958..3396965	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15720.03 Da
• Isoelectric Point: 10.4623

>T168106 WP_009518132.1 NZ_CP059041:c3392217-3391828 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFINFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKKLTSIIWFDQMSLTEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168106 NZ_CP075633:2852-3127 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
CGCCGCCAGAATGGTACAGTCCCTGATACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9842.27 Da
• Isoelectric Point: 4.9001

>AT168106 WP_011860336.1 NZ_CP059041:c3392469-3392224 [Acinetobacter baumannii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLKHYVH
G

Nucleotide

• Length: 246 bp

>AT168106 NZ_CP075633:2568-2852 [Escherichia coli]
ATACAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCACTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGATATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAGTACTGACAATCCGTTACCGGTTCCACGCTGA

Structures

Toxin

• AlphaFold DB: A0A1E3M967