Detailed information of TA system TA168104

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1934942..1936578
• Replicon: chromosome
• Accession: NZ_CP059041
• Organism: Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: H0N28_RS09195
• Protein ID: WP_000737056.1
• Coordinates: 1935247..1936578 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H0N28_RS09190
• Protein ID: WP_001101308.1
• Coordinates: 1934942..1935250 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0N28_RS09165	1930507..1931025	-	519	WP_000651611.1	GNAT family N-acetyltransferase	-
H0N28_RS09170	1931226..1931687	-	462	WP_190269552.1	hypothetical protein	-
H0N28_RS09175	1931729..1932811	-	1083	WP_001095788.1	ImmA/IrrE family metallo-endopeptidase	-
H0N28_RS09180	1932829..1933449	-	621	WP_000658761.1	hypothetical protein	-
H0N28_RS09185	1933665..1934216	-	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
H0N28_RS09190	1934942..1935250	-	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
H0N28_RS09195	1935247..1936578	-	1332	WP_000737056.1	type II toxin-antitoxin system HipA family toxin	Toxin
H0N28_RS09200	1936874..1937314	+	441	WP_000193135.1	HD domain-containing protein	-
H0N28_RS09205	1937349..1937993	-	645	WP_000817301.1	hypothetical protein	-
H0N28_RS09210	1938005..1938976	-	972	WP_109104914.1	acid phosphatase	-
H0N28_RS09215	1939103..1940263	-	1161	WP_001044492.1	hypothetical protein	-
H0N28_RS09220	1940256..1941494	-	1239	WP_011859301.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T168104 WP_000737056.1 NZ_CP059041:c1936578-1935247 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T168104 NZ_CP075632:4582897-4583232 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT168104 WP_001101308.1 NZ_CP059041:c1935250-1934942 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT168104 NZ_CP075632:4582649-4582897 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1