Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1934942..1936578 Replicon chromosome
Accession NZ_CP059041
Organism Acinetobacter baumannii strain ATCC 17978

Toxin (Protein)


Gene name hipA Uniprot ID A0A1E3M7C1
Locus tag H0N28_RS09195 Protein ID WP_000737056.1
Coordinates 1935247..1936578 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag H0N28_RS09190 Protein ID WP_001101308.1
Coordinates 1934942..1935250 (-) Length 103 a.a.

Genomic Context

H0N28_RS09200H0N28_RS09165H0N28_RS09170H0N28_RS09175H0N28_RS09180H0N28_RS09185H0N28_RS09190H0N28_RS09195H0N28_RS09205H0N28_RS09210H0N28_RS09215H0N28_RS09220
Location: 1936874..1937314 (441 bp)
Type: Others
Protein ID: WP_000193135.1
Location: 1930507..1931025 (519 bp)
Type: Others
Protein ID: WP_000651611.1
Location: 1931226..1931687 (462 bp)
Type: Others
Protein ID: WP_190269552.1
Location: 1931729..1932811 (1083 bp)
Type: Others
Protein ID: WP_001095788.1
Location: 1932829..1933449 (621 bp)
Type: Others
Protein ID: WP_000658761.1
Location: 1933665..1934216 (552 bp)
Type: Others
Protein ID: WP_049594830.1
Location: 1934942..1935250 (309 bp)
Type: Antitoxin
Protein ID: WP_001101308.1
Location: 1935247..1936578 (1332 bp)
Type: Toxin
Protein ID: WP_000737056.1
Location: 1937349..1937993 (645 bp)
Type: Others
Protein ID: WP_000817301.1
Location: 1938005..1938976 (972 bp)
Type: Others
Protein ID: WP_109104914.1
Location: 1939103..1940263 (1161 bp)
Type: Others
Protein ID: WP_001044492.1
Location: 1940256..1941494 (1239 bp)
Type: Others
Protein ID: WP_011859301.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
H0N28_RS091651930507..1931025-519WP_000651611.1GNAT family N-acetyltransferase-
H0N28_RS091701931226..1931687-462WP_190269552.1hypothetical protein-
H0N28_RS091751931729..1932811-1083WP_001095788.1ImmA/IrrE family metallo-endopeptidase-
H0N28_RS091801932829..1933449-621WP_000658761.1hypothetical protein-
H0N28_RS091851933665..1934216-552WP_049594830.1TetR/AcrR family transcriptional regulator-
H0N28_RS091901934942..1935250-309WP_001101308.1helix-turn-helix domain-containing proteinAntitoxin
H0N28_RS091951935247..1936578-1332WP_000737056.1type II toxin-antitoxin system HipA family toxinToxin
H0N28_RS092001936874..1937314+441WP_000193135.1HD domain-containing protein-
H0N28_RS092051937349..1937993-645WP_000817301.1hypothetical protein-
H0N28_RS092101938005..1938976-972WP_109104914.1acid phosphatase-
H0N28_RS092151939103..1940263-1161WP_001044492.1hypothetical protein-
H0N28_RS092201940256..1941494-1239WP_011859301.1TolC family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51189.16 Da        Isoelectric Point: 4.7456

>T168104 WP_000737056.1 NZ_CP059041:c1936578-1935247 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T168104 NZ_CP075632:4582897-4583232 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.55 Da        Isoelectric Point: 9.9701

>AT168104 WP_001101308.1 NZ_CP059041:c1935250-1934942 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT168104 NZ_CP075632:4582649-4582897 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A1E3M7C1

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References