Detailed information of TA system TA168102

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1820027..1821663
• Replicon: chromosome
• Accession: NZ_CP059039
• Organism: Acinetobacter baumannii strain A118

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8B4MZ76
• Locus tag: H0N27_RS08435
• Protein ID: WP_000737058.1
• Coordinates: 1820027..1821358 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: H0N27_RS08440
• Protein ID: WP_001101310.1
• Coordinates: 1821355..1821663 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0N27_RS08415	1816339..1817502	+	1164	WP_168726226.1	hypothetical protein	-
H0N27_RS08420	1817629..1818600	+	972	WP_168726227.1	acid phosphatase	-
H0N27_RS08425	1818612..1819256	+	645	WP_032000318.1	hypothetical protein	-
H0N27_RS08430	1819291..1819731	-	441	WP_168726228.1	HD domain-containing protein	-
H0N27_RS08435	1820027..1821358	+	1332	WP_000737058.1	type II toxin-antitoxin system HipA family toxin	Toxin
H0N27_RS08440	1821355..1821663	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
H0N27_RS08445	1822386..1822934	+	549	WP_168726229.1	TetR/AcrR family transcriptional regulator	-
H0N27_RS08450	1823052..1824050	+	999	WP_168726230.1	adenosine deaminase	-
H0N27_RS08455	1824051..1824593	+	543	WP_168726231.1	non-canonical purine NTP pyrophosphatase	-
H0N27_RS08460	1824590..1825426	+	837	WP_168726232.1	SIR2 family protein	-
H0N27_RS08465	1825604..1826122	+	519	WP_168726233.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51202.34 Da
• Isoelectric Point: 4.9820

>T168102 WP_000737058.1 NZ_CP059039:1820027-1821358 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T168102 NZ_CP075632:c4149445-4148981 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT168102 WP_001101310.1 NZ_CP059039:1821355-1821663 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT168102 NZ_CP075632:c4149780-4149445 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A8B4MZ76