Detailed information of TA system TA168101

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 449151..449804
• Replicon: chromosome
• Accession: NZ_CP059039
• Organism: Acinetobacter baumannii strain A118

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H0N27_RS02160
• Protein ID: WP_168726711.1
• Coordinates: 449415..449804 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H0N27_RS02155
• Protein ID: WP_001288210.1
• Coordinates: 449151..449408 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0N27_RS02135	444666..445673	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H0N27_RS02140	445692..446069	+	378	WP_001216380.1	50S ribosomal protein L17	-
H0N27_RS02145	446251..447741	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
H0N27_RS02150	447791..448963	-	1173	WP_032061191.1	acyl-CoA dehydrogenase family protein	-
H0N27_RS02155	449151..449408	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H0N27_RS02160	449415..449804	+	390	WP_168726711.1	hypothetical protein	Toxin
H0N27_RS02165	450574..451659	+	1086	WP_000049106.1	hypothetical protein	-
H0N27_RS02170	451737..452303	+	567	WP_000651536.1	rhombosortase	-
H0N27_RS02175	452491..454686	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15736.07 Da
• Isoelectric Point: 10.3599

>T168101 WP_168726711.1 NZ_CP059039:449415-449804 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLVEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T168101 NZ_CP075632:3823888-3824118 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT168101 WP_001288210.1 NZ_CP059039:449151-449408 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT168101 NZ_CP075632:3824115-3824474 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTTTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7