Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4809122..4809920 Replicon chromosome
Accession NZ_CP059003
Organism Escherichia coli strain 2D

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag H0E72_RS23110 Protein ID WP_000854735.1
Coordinates 4809543..4809920 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag H0E72_RS23105 Protein ID WP_001285415.1
Coordinates 4809122..4809496 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0E72_RS23070 4805054..4805734 + 681 WP_001282919.1 WYL domain-containing protein -
H0E72_RS23075 4805882..4806559 + 678 WP_001097301.1 hypothetical protein -
H0E72_RS23080 4806565..4806798 + 234 WP_001278287.1 DUF905 family protein -
H0E72_RS23085 4806888..4807706 + 819 WP_113344608.1 DUF945 domain-containing protein -
H0E72_RS23090 4807788..4808267 + 480 WP_001757700.1 antirestriction protein -
H0E72_RS23095 4808282..4808758 + 477 WP_001342696.1 RadC family protein -
H0E72_RS23100 4808821..4809042 + 222 WP_000692309.1 DUF987 domain-containing protein -
H0E72_RS23105 4809122..4809496 + 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H0E72_RS23110 4809543..4809920 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
H0E72_RS23115 4809917..4810405 + 489 WP_000761680.1 hypothetical protein -
H0E72_RS23120 4810423..4810620 + 198 WP_000839266.1 DUF957 domain-containing protein -
H0E72_RS23125 4810717..4811559 + 843 WP_000036707.1 DUF4942 domain-containing protein -
H0E72_RS23130 4811808..4811954 + 147 WP_001328030.1 hypothetical protein -
H0E72_RS23135 4812336..4813520 + 1185 WP_001172866.1 sugar efflux transporter -
H0E72_RS23140 4813631..4814554 + 924 WP_000535950.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T168095 WP_000854735.1 NZ_CP059003:4809543-4809920 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T168095 NZ_CP075632:2301772-2302050 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT168095 WP_001285415.1 NZ_CP059003:4809122-4809496 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT168095 NZ_CP075632:2301509-2301769 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References