Detailed information of TA system TA168094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4520816..4521459
• Replicon: chromosome
• Accession: NZ_CP059003
• Organism: Escherichia coli strain 2D

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H0E72_RS21800
• Protein ID: WP_049038273.1
• Coordinates: 4521172..4521459 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: U9Y7E1
• Locus tag: H0E72_RS21795
• Protein ID: WP_000593555.1
• Coordinates: 4520816..4521175 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0E72_RS21765	4515931..4516404	+	474	WP_012311717.1	PTS sugar transporter subunit IIA	-
H0E72_RS21770	4516401..4516682	+	282	WP_000084021.1	PTS sugar transporter subunit IIB	-
H0E72_RS21775	4516756..4518114	+	1359	WP_001302220.1	PTS galactitol transporter subunit IIC	-
H0E72_RS21780	4518107..4519615	+	1509	WP_012311797.1	carbohydrate kinase	-
H0E72_RS21785	4519605..4519874	+	270	WP_000949581.1	HPr family phosphocarrier protein	-
H0E72_RS21790	4519906..4520766	+	861	WP_001131792.1	class II aldolase	-
H0E72_RS21795	4520816..4521175	-	360	WP_000593555.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H0E72_RS21800	4521172..4521459	-	288	WP_049038273.1	type II toxin-antitoxin system HicA family toxin	Toxin
H0E72_RS21805	4521519..4522643	-	1125	WP_001314210.1	ABC transporter permease	-
H0E72_RS21810	4522643..4525378	-	2736	WP_000149118.1	ribosome-associated ATPase/putative transporter RbbA	-
H0E72_RS21815	4525375..4526442	-	1068	WP_000361481.1	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (34-84)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10490.98 Da
• Isoelectric Point: 7.7845

>T168094 WP_049038273.1 NZ_CP059003:c4521459-4521172 [Escherichia coli]
IRTCHENPGTGFTEETKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGA
VESVRDWLLSIGVKP

Nucleotide

• Length: 288 bp

>T168094 NZ_CP075632:2121289-2121831 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13402.27 Da
• Isoelectric Point: 5.1987

>AT168094 WP_000593555.1 NZ_CP059003:c4521175-4520816 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Nucleotide

• Length: 360 bp

>AT168094 NZ_CP075632:2120994-2121305 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9LKZ6