Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-Xre
Location 7547..8445 Replicon plasmid pHP17a
Accession NZ_CP059000
Organism Mycobacterium avium subsp. hominissuis strain HP17

Toxin (Protein)


Gene name mbcT Uniprot ID A0A859PX34
Locus tag BEP52_RS23750 Protein ID WP_023870434.1
Coordinates 7885..8445 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A859PYE6
Locus tag BEP52_RS23745 Protein ID WP_023870435.1
Coordinates 7547..7888 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BEP52_RS23715 2581..3423 + 843 WP_023870443.1 ParB/RepB/Spo0J family partition protein -
BEP52_RS23720 3639..3890 + 252 WP_023870442.1 ribbon-helix-helix protein, CopG family -
BEP52_RS23725 3887..4303 + 417 WP_023870441.1 type II toxin-antitoxin system VapC family toxin -
BEP52_RS23730 4408..4848 - 441 WP_023870440.1 hypothetical protein -
BEP52_RS23735 5024..5185 + 162 WP_023870439.1 hypothetical protein -
BEP52_RS23740 6307..7458 - 1152 WP_023870436.1 hypothetical protein -
BEP52_RS23745 7547..7888 + 342 WP_023870435.1 DUF2384 domain-containing protein Antitoxin
BEP52_RS23750 7885..8445 + 561 WP_023870434.1 RES domain-containing protein Toxin
BEP52_RS23755 8661..9011 - 351 WP_023870433.1 hypothetical protein -
BEP52_RS23760 9008..10711 - 1704 WP_158423352.1 WXG100 family type VII secretion target -
BEP52_RS23765 10728..11033 - 306 WP_023870373.1 hypothetical protein -
BEP52_RS23770 11109..11414 - 306 WP_134798478.1 hypothetical protein -
BEP52_RS23775 11444..12988 - 1545 WP_134798479.1 DUF4226 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - esxN / eccA5 / esxN 1..150076 150076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(27-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20272.58 Da        Isoelectric Point: 4.8677

>T168071 WP_023870434.1 NZ_CP059000:7885-8445 [Mycobacterium avium subsp. hominissuis]
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK

Download         Length: 561 bp

>T168071 NZ_CP075627:c1942953-1942846 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12350.16 Da        Isoelectric Point: 5.0916

>AT168071 WP_023870435.1 NZ_CP059000:7547-7888 [Mycobacterium avium subsp. hominissuis]
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV

Download         Length: 342 bp

>AT168071 NZ_CP075627:1943000-1943066 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A859PX34

Antitoxin

Source ID Structure
AlphaFold DB A0A859PYE6

References