Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-Xre
Location 7547..8445 Replicon plasmid pHP17a
Accession NZ_CP059000
Organism Mycobacterium avium subsp. hominissuis strain HP17

Toxin (Protein)


Gene name mbcT Uniprot ID A0A859PX34
Locus tag BEP52_RS23750 Protein ID WP_023870434.1
Coordinates 7885..8445 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID A0A859PYE6
Locus tag BEP52_RS23745 Protein ID WP_023870435.1
Coordinates 7547..7888 (+) Length 114 a.a.

Genomic Context

BEP52_RS23715BEP52_RS23720BEP52_RS23725BEP52_RS23735BEP52_RS23745BEP52_RS23750BEP52_RS23730BEP52_RS23740BEP52_RS23755BEP52_RS23760BEP52_RS23765BEP52_RS23770BEP52_RS23775
Location: 2581..3423 (843 bp)
Type: Others
Protein ID: WP_023870443.1
Location: 3639..3890 (252 bp)
Type: Others
Protein ID: WP_023870442.1
Location: 3887..4303 (417 bp)
Type: Others
Protein ID: WP_023870441.1
Location: 5024..5185 (162 bp)
Type: Others
Protein ID: WP_023870439.1
Location: 7547..7888 (342 bp)
Type: Antitoxin
Protein ID: WP_023870435.1
Location: 7885..8445 (561 bp)
Type: Toxin
Protein ID: WP_023870434.1
Location: 4408..4848 (441 bp)
Type: Others
Protein ID: WP_023870440.1
Location: 6307..7458 (1152 bp)
Type: Others
Protein ID: WP_023870436.1
Location: 8661..9011 (351 bp)
Type: Others
Protein ID: WP_023870433.1
Location: 9008..10711 (1704 bp)
Type: Others
Protein ID: WP_158423352.1
Location: 10728..11033 (306 bp)
Type: Others
Protein ID: WP_023870373.1
Location: 11109..11414 (306 bp)
Type: Others
Protein ID: WP_134798478.1
Location: 11444..12988 (1545 bp)
Type: Others
Protein ID: WP_134798479.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BEP52_RS237152581..3423+843WP_023870443.1ParB/RepB/Spo0J family partition protein-
BEP52_RS237203639..3890+252WP_023870442.1ribbon-helix-helix protein, CopG family-
BEP52_RS237253887..4303+417WP_023870441.1type II toxin-antitoxin system VapC family toxin-
BEP52_RS237304408..4848-441WP_023870440.1hypothetical protein-
BEP52_RS237355024..5185+162WP_023870439.1hypothetical protein-
BEP52_RS237406307..7458-1152WP_023870436.1hypothetical protein-
BEP52_RS237457547..7888+342WP_023870435.1DUF2384 domain-containing proteinAntitoxin
BEP52_RS237507885..8445+561WP_023870434.1RES domain-containing proteinToxin
BEP52_RS237558661..9011-351WP_023870433.1hypothetical protein-
BEP52_RS237609008..10711-1704WP_158423352.1WXG100 family type VII secretion target-
BEP52_RS2376510728..11033-306WP_023870373.1hypothetical protein-
BEP52_RS2377011109..11414-306WP_134798478.1hypothetical protein-
BEP52_RS2377511444..12988-1545WP_134798479.1DUF4226 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-esxN / eccA5 / esxN1..150076150076


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(27-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20272.58 Da        Isoelectric Point: 4.8677

>T168071 WP_023870434.1 NZ_CP059000:7885-8445 [Mycobacterium avium subsp. hominissuis]
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK

Download         Length: 561 bp

>T168071 NZ_CP075627:c1942953-1942846 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12350.16 Da        Isoelectric Point: 5.0916

>AT168071 WP_023870435.1 NZ_CP059000:7547-7888 [Mycobacterium avium subsp. hominissuis]
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV

Download         Length: 342 bp

>AT168071 NZ_CP075627:1943000-1943066 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A859PX34

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A859PYE6

References