Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 856458..857032 Replicon chromosome
Accession NZ_CP058991
Organism Pasteurella multocida strain A0419

Toxin (Protein)


Gene name PumA Uniprot ID A0A849CFF7
Locus tag H0H21_RS03935 Protein ID WP_014667974.1
Coordinates 856748..857032 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A849CG04
Locus tag H0H21_RS03930 Protein ID WP_014391174.1
Coordinates 856458..856751 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0H21_RS03910 851623..852714 - 1092 WP_005756839.1 L-ascorbate 6-phosphate lactonase -
H0H21_RS03915 853063..854853 + 1791 WP_016534552.1 PTS ascorbate-specific subunit IIBC -
H0H21_RS03920 854898..855365 + 468 WP_014391172.1 PTS sugar transporter subunit IIA -
H0H21_RS03925 855383..856060 + 678 WP_014391173.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
H0H21_RS03930 856458..856751 - 294 WP_014391174.1 putative addiction module antidote protein Antitoxin
H0H21_RS03935 856748..857032 - 285 WP_014667974.1 addiction module protein Toxin
H0H21_RS03945 858326..858587 - 262 Protein_749 hypothetical protein -
H0H21_RS03950 858759..859084 - 326 Protein_750 hypothetical protein -
H0H21_RS03955 859384..861570 - 2187 WP_014667973.1 S8 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 858326..858487 161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-85)

Antitoxin

Uncharacterized protein HI1420

(5-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10702.41 Da        Isoelectric Point: 10.2849

>T168066 WP_014667974.1 NZ_CP058991:c857032-856748 [Pasteurella multocida]
VGRLREVKNLSAKAAVLARINRVMNGNLGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T168066 NZ_CP075627:c996542-996000 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.80 Da        Isoelectric Point: 8.9149

>AT168066 WP_014391174.1 NZ_CP058991:c856751-856458 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALADVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKITHSLGIKLVPTHI

Download         Length: 294 bp

>AT168066 NZ_CP075627:c996837-996526 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A849CFF7

Antitoxin

Source ID Structure
AlphaFold DB A0A849CG04

References