Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1713604..1714119 Replicon chromosome
Accession NZ_CP058971
Organism Micrococcus luteus strain V017

Toxin (Protein)


Gene name relE Uniprot ID A0A4Y1LR91
Locus tag H0H31_RS07735 Protein ID WP_041103932.1
Coordinates 1713604..1713858 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A229HG25
Locus tag H0H31_RS07740 Protein ID WP_036340860.1
Coordinates 1713859..1714119 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0H31_RS07705 1709122..1710528 + 1407 WP_020624988.1 Dyp-type peroxidase -
H0H31_RS07710 1710525..1710914 + 390 WP_185194403.1 hypothetical protein -
H0H31_RS07715 1710946..1711671 + 726 WP_185194404.1 MSMEG_4193 family putative phosphomutase -
H0H31_RS07720 1711668..1712210 + 543 WP_144825255.1 DUF3090 domain-containing protein -
H0H31_RS07725 1712210..1712992 + 783 WP_185194405.1 SCO1664 family protein -
H0H31_RS07730 1713036..1713602 - 567 WP_041103934.1 mismatch-specific DNA-glycosylase -
H0H31_RS07735 1713604..1713858 - 255 WP_041103932.1 Txe/YoeB family addiction module toxin Toxin
H0H31_RS07740 1713859..1714119 - 261 WP_036340860.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H0H31_RS07745 1714305..1715404 + 1100 Protein_1501 GntP family permease -
H0H31_RS07750 1715434..1716588 + 1155 WP_134416956.1 glycerate kinase -
H0H31_RS07755 1716584..1717000 + 417 Protein_1503 phosphatidylinositol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9996.33 Da        Isoelectric Point: 7.3149

>T168065 WP_041103932.1 NZ_CP058971:c1713858-1713604 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Download         Length: 255 bp

>T168065 NZ_CP075627:c821395-821117 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9597.74 Da        Isoelectric Point: 4.8359

>AT168065 WP_036340860.1 NZ_CP058971:c1714119-1713859 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Download         Length: 261 bp

>AT168065 NZ_CP075627:c821658-821398 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y1LR91

Antitoxin

Source ID Structure
AlphaFold DB A0A229HG25

References