Detailed information of TA system TA168064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 6250350..6252033
• Replicon: chromosome
• Accession: NZ_CP058970
• Organism: Delftia acidovorans strain B804

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: H0G62_RS28575
• Protein ID: WP_180318270.1
• Coordinates: 6251179..6252033 (-)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: F6ALN8
• Locus tag: H0G62_RS28570
• Protein ID: WP_012202883.1
• Coordinates: 6250350..6251156 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0G62_RS28545	6245457..6246380	-	924	WP_180318268.1	IclR family transcriptional regulator	-
H0G62_RS28550	6246392..6247162	-	771	WP_180318269.1	SDR family oxidoreductase	-
H0G62_RS28555	6247996..6248271	+	276	WP_012202887.1	hypothetical protein	-
H0G62_RS28560	6248639..6249394	-	756	WP_012202885.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
H0G62_RS28565	6249498..6250295	-	798	WP_043825460.1	aspartate dehydrogenase	-
H0G62_RS28570	6250350..6251156	-	807	WP_012202883.1	IclR family transcriptional regulator	Antitoxin
H0G62_RS28575	6251179..6252033	-	855	WP_180318270.1	alpha/beta fold hydrolase	Toxin
H0G62_RS28580	6252183..6252713	-	531	WP_012202881.1	cupin domain-containing protein	-
H0G62_RS28585	6252913..6254109	-	1197	WP_180318271.1	MFS transporter	-
H0G62_RS28590	6254132..6255016	-	885	WP_180318272.1	NAD(P)-dependent oxidoreductase	-
H0G62_RS28595	6255153..6255743	-	591	WP_180318273.1	TetR/AcrR family transcriptional regulator	-
H0G62_RS28600	6255825..6256316	-	492	WP_180318274.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (43-270)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 29484.76 Da
• Isoelectric Point: 6.7440

>T168064 WP_180318270.1 NZ_CP058970:c6252033-6251179 [Delftia acidovorans]
MTPSVTACMEQRLQAQFSEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALALAPRTRVLAWDAPGYGR
STPLAPDAPTGADYARMLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Nucleotide

• Length: 855 bp

>T168064 NZ_CP075627:276666-276839 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29330.45 Da
• Isoelectric Point: 5.7085

>AT168064 WP_012202883.1 NZ_CP058970:c6251156-6250350 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT168064 NZ_CP075627:276342-276638 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A031HDN8