Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5472152..5472783 Replicon chromosome
Accession NZ_CP058970
Organism Delftia acidovorans strain B804

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H0G62_RS25025 Protein ID WP_180318010.1
Coordinates 5472152..5472553 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H0G62_RS25030 Protein ID WP_180318011.1
Coordinates 5472550..5472783 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0G62_RS24990 5467461..5468276 + 816 WP_180318004.1 hypothetical protein -
H0G62_RS24995 5468273..5469091 + 819 WP_180318005.1 hypothetical protein -
H0G62_RS25000 5469078..5469485 + 408 WP_180318006.1 hypothetical protein -
H0G62_RS25005 5469493..5469870 + 378 WP_180317090.1 hypothetical protein -
H0G62_RS25010 5469867..5470403 + 537 WP_180318007.1 hypothetical protein -
H0G62_RS25015 5470400..5470633 + 234 WP_180318008.1 hypothetical protein -
H0G62_RS25020 5470621..5471748 + 1128 WP_180318009.1 site-specific integrase -
H0G62_RS25025 5472152..5472553 - 402 WP_180318010.1 type II toxin-antitoxin system VapC family toxin Toxin
H0G62_RS25030 5472550..5472783 - 234 WP_180318011.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
H0G62_RS25035 5472940..5473482 - 543 WP_180318012.1 helix-turn-helix domain-containing protein -
H0G62_RS25040 5473616..5474296 + 681 WP_180318013.1 hypothetical protein -
H0G62_RS25045 5474376..5474999 + 624 WP_180318014.1 glutathione transferase -
H0G62_RS25050 5475021..5475245 + 225 WP_012203534.1 hypothetical protein -
H0G62_RS25055 5475279..5475812 - 534 WP_180318015.1 DUF2939 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5431977..5474296 42319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(7-27)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14458.81 Da        Isoelectric Point: 5.8323

>T168063 WP_180318010.1 NZ_CP058970:c5472553-5472152 [Delftia acidovorans]
MILLDTNICIYIINAKPPEVLARFQQYRMGEVGLCSVVAAELAFGVAKSGSARNRQALEMFLAPLAILPFDEAAVWAYGD
LRADLERRGSPIGALDTMIAAHALSQRALLVTNNTREFAKVPGLQLDNWAVAT

Download         Length: 402 bp

>T168063 NZ_CP075607:43315-43416 [Enterococcus faecalis]
GTGAAAGATTTAATGTCGTTGGTTATCGCACCAATCTTTGTAGGATTGGTTCTGGAAATGATTTCTCGTGTGTTGGACGA
GGAAGACGATAGCCGAAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8699.76 Da        Isoelectric Point: 4.5338

>AT168063 WP_180318011.1 NZ_CP058970:c5472783-5472550 [Delftia acidovorans]
MDTARLFQSGRSQAVRLPKEYRFTGTEVVVKHFGNGVLLLPADDPWQTLQAGLAEFEPGFVLEREQPEAQQRDEISP

Download         Length: 234 bp

>AT168063 NZ_CP075607:c43520-43456 [Enterococcus faecalis]
AACGACATTAAATCGTACAGATAACACAAAAAGCAATCCTACGGCGAATAGGATTGCTTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References