Detailed information of TA system TA168062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1482376..1483085
• Replicon: chromosome
• Accession: NZ_CP058970
• Organism: Delftia acidovorans strain B804

Toxin (Protein)

• Gene name: tad
• Uniprot ID: A0A210VR27
• Locus tag: H0G62_RS06675
• Protein ID: WP_011805136.1
• Coordinates: 1482702..1483085 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: H0G62_RS06670
• Protein ID: WP_011805135.1
• Coordinates: 1482376..1482705 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0G62_RS06655	1478316..1478648	+	333	Protein_1308	PRC-barrel domain-containing protein	-
H0G62_RS06660	1478984..1481899	-	2916	WP_003049965.1	Tn3-like element IS1071 family transposase	-
H0G62_RS06665	1482040..1482363	+	324	Protein_1310	site-specific integrase	-
H0G62_RS06670	1482376..1482705	-	330	WP_011805135.1	helix-turn-helix domain-containing protein	Antitoxin
H0G62_RS06675	1482702..1483085	-	384	WP_011805136.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0G62_RS06680	1483162..1483755	+	594	WP_088167134.1	ABC transporter substrate-binding protein	-
H0G62_RS06685	1483893..1485372	+	1480	Protein_1314	aldehyde dehydrogenase	-
H0G62_RS06690	1485420..1486475	+	1056	WP_017404448.1	zinc-binding dehydrogenase	-
H0G62_RS06695	1486576..1487433	-	858	WP_103738775.1	carboxylating nicotinate-nucleotide diphosphorylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1352206..1563867	211661
	-	flank	IS/Tn	-	-	1478984..1481899	2915

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (18-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14062.15 Da
• Isoelectric Point: 10.0145

>T168062 WP_011805136.1 NZ_CP058970:c1483085-1482702 [Delftia acidovorans]
MSTQPRKPLKWVGSAKRDLDGMPEDVQDVFGHAIDLAQAGGKHPDAKALSGFGSAAVLEVVEDFRSDTFRAVYTVKFAGW
VYVLHCFQKKSKSGIKTPKEDLDLIKARLKAAVQDFEAWQAKQGVKR

Nucleotide

• Length: 384 bp

>T168062 NZ_CP075607:c38793-38431 [Enterococcus faecalis]
ATGGTAAAAGTTCCTCATCAAGGTGATATTTTATTGTTGAATACGGCTCCTAGATCAGGACATGAACAAACAGGTAAGAG
ACCGTATATTGTTTTAAGTCATGATATTATTGCAGATTACAGCAATGTTGTTATTGTAGCTCCTATATCAAGTACAAAAA
GAAACTATCCTTTATATGTTTCTATTAATCCTTCTTACGGAATGAAAACATCAGGTAAAGTATTATTAGATCAATTAACC
ACCATCGATTATGAGGCTAGACAATGCGTGTTTTTAGAAACAGCACACGAAAAATTAATCGATGAATTATTGCTAAAAGT
TAGAACCGTATTTCAAAAAGTAAATAAAACAAATAAATTTTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11929.73 Da
• Isoelectric Point: 10.5281

>AT168062 WP_011805135.1 NZ_CP058970:c1482705-1482376 [Delftia acidovorans]
MSQNSHITIEEGSTNVYADLGYADAAEMQRKSQLAAEIARAIKARRLTQQGAAALLEIDQSKISRITRGQFRGVSEAKLL
ELVAKLGHDVKIVVGPVRRRAGKIELQFA

Nucleotide

• Length: 330 bp

>AT168062 NZ_CP075607:c39050-38787 [Enterococcus faecalis]
ATGGTAATGTTATCAATAAAAAAATGGGGCAATAGTAACGGTCTTAGACTTCCTAAATCTGTGATGGAATATCTCCAAAT
TCATACAGAAGATAAAGTGAAAATAACACAGGAGGAATCGAATGGTAAAAAACGATTAATTATTGAAGCTGTGGATTCTG
ATAATGATTTAACAATTGAACAATTGTTTGAAAATTATAAAGAAGAGAAGGTGCATGTAACTATTCAAGATTTAGGAAAT
GCGGTAGGAAATGAAAAATGGTAA

Structures

Toxin

• AlphaFold DB: A0A210VR27