Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4206876..4207495 Replicon chromosome
Accession NZ_CP058960
Organism Klebsiella pneumoniae strain ZZW20

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag H0E90_RS21200 Protein ID WP_002892050.1
Coordinates 4207277..4207495 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag H0E90_RS21195 Protein ID WP_002892066.1
Coordinates 4206876..4207250 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0E90_RS21185 4202028..4203221 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
H0E90_RS21190 4203244..4206390 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
H0E90_RS21195 4206876..4207250 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
H0E90_RS21200 4207277..4207495 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
H0E90_RS21205 4207654..4208220 + 567 WP_002892030.1 maltose O-acetyltransferase -
H0E90_RS21210 4208192..4208332 - 141 WP_004147370.1 hypothetical protein -
H0E90_RS21215 4208353..4208823 + 471 WP_002892026.1 YlaC family protein -
H0E90_RS21220 4208798..4210249 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
H0E90_RS21225 4210350..4211048 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
H0E90_RS21230 4211045..4211185 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
H0E90_RS21235 4211185..4211448 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T168053 WP_002892050.1 NZ_CP058960:4207277-4207495 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T168053 NZ_CP075604:3147441-3147563 [Enterococcus faecalis]
ATGAAAGGAGTAGGCCTTTTGTCAGCATATGAGACAATTCAGACGATCCTAGGGTTTGGTATGTTTACCATTGCTTTGAT
TGCACTGATTGTGAAATTGCTTAAAGAAGACAAAAAGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT168053 WP_002892066.1 NZ_CP058960:4206876-4207250 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT168053 NZ_CP075604:c3147703-3147496 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAA
TGGTGACAAAATTTTAAAGATTTTGAAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTT
TAAGCAATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References