Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869077..869734 Replicon chromosome
Accession NZ_CP058960
Organism Klebsiella pneumoniae strain ZZW20

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H0E90_RS04380 Protein ID WP_002916310.1
Coordinates 869324..869734 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H0E90_RS04375 Protein ID WP_002916312.1
Coordinates 869077..869343 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0E90_RS04350 864233..865666 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
H0E90_RS04355 865785..866513 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H0E90_RS04360 866563..866874 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
H0E90_RS04365 867038..867697 + 660 WP_002916317.1 hemolysin III family protein -
H0E90_RS04370 867848..868831 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
H0E90_RS04375 869077..869343 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H0E90_RS04380 869324..869734 + 411 WP_002916310.1 protein YgfX Toxin
H0E90_RS04385 869741..870262 - 522 WP_002916308.1 flavodoxin FldB -
H0E90_RS04390 870363..871259 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H0E90_RS04395 871282..871995 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0E90_RS04400 872001..873734 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T168043 WP_002916310.1 NZ_CP058960:869324-869734 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T168043 NZ_CP075595:c678293-677991 [Pseudomonas sp. RC3H12]
ATGAAAACCATCGAATCCAGCAGTTTCAGGCATTGGCTGATCGGGCTTCGGGATGCCACGGCAAGGGCCAGAATCGTCGC
TCGTGTCAACCGACTCAAGGAAGGGCTAGCGGGTGACGTTTCACCGGTCGGCCATGGCATGAGTGAGCTGAGAGTCCATT
ACGGCCCAGGCTATCGGGTGTATTTTCACCAATACGGCGATACCTTGATCATCCTGCTTTGCGGCGGCGACAAAAGCAGC
CAGCAACGGGACATCAAGGCAGCCCGGCAGATCCTGCAGTCGTGGAGGATGCAAAATGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT168043 WP_002916312.1 NZ_CP058960:869077-869343 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT168043 NZ_CP075595:c677998-677693 [Pseudomonas sp. RC3H12]
ATGACTGAAACGTTCCATGAGTTCGACGCCGCCGCCTATCTGACTTCCCCGGAAACCATCGCGCAGTTCATGACCGATGC
ATTGGAGACAGGGGATGCAGCCTACGTAGCAAAAGCCGTGGGCGTGGTGGCTCGCGCCAGGGGCATGAGTGAACTGGCAA
AGGAAACAGGCCTGTCTCGCGAGCAGCTTTACCGCTCGTTCAGTGAACACGGCAACCCAACGCTCAAATCGTTCCTGACT
GTAATGAAAGCGTTGGGAATAGACATGGCTGCCAGACCCCACTTATCCCAGCAAGGTGTAGGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References