Detailed information of TA system TA168038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 4085323..4085914
• Replicon: chromosome
• Accession: NZ_CP058958
• Organism: Providencia rettgeri strain G0519

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H0A34_RS18740
• Protein ID: WP_180312194.1
• Coordinates: 4085323..4085646 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D4C3P0
• Locus tag: H0A34_RS18745
• Protein ID: WP_004905876.1
• Coordinates: 4085627..4085914 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0A34_RS18710	4081031..4081282	-	252	WP_096864324.1	DUF1471 domain-containing protein	-
H0A34_RS18715	4081553..4081891	+	339	WP_004905864.1	GIY-YIG nuclease family protein	-
H0A34_RS18720	4081864..4082367	-	504	WP_004905865.1	N-acetyltransferase	-
H0A34_RS18725	4082361..4082885	-	525	WP_094961643.1	SCP2 domain-containing protein	-
H0A34_RS18730	4083400..4084395	+	996	WP_094961644.1	U32 family peptidase	-
H0A34_RS18735	4084413..4085288	+	876	WP_094961645.1	U32 family peptidase	-
H0A34_RS18740	4085323..4085646	-	324	WP_180312194.1	type II toxin-antitoxin system YafQ family toxin	Toxin
H0A34_RS18745	4085627..4085914	-	288	WP_004905876.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
H0A34_RS18750	4086045..4087199	-	1155	WP_004905877.1	ABC transporter permease	-
H0A34_RS18755	4087199..4088344	-	1146	WP_004905879.1	ABC transporter permease	-
H0A34_RS18760	4088356..4089327	-	972	WP_094961646.1	efflux RND transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (14-105)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (10-75)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12462.22 Da
• Isoelectric Point: 9.4387

>T168038 WP_180312194.1 NZ_CP058958:c4085646-4085323 [Providencia rettgeri]
MTQKPSNKRAKQPRQVAYTPTFKESWERYNRAGRRDMNAAVLVMEILFSQKIIPKEYLDHELEGHEWQGARELHIGGDFL
LVYRLSDKGNLITFVDIGSHSELFGVR

Nucleotide

• Length: 324 bp

>T168038 NZ_CP075591:c4822607-4822323 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10763.44 Da
• Isoelectric Point: 5.8809

>AT168038 WP_004905876.1 NZ_CP058958:c4085914-4085627 [Providencia rettgeri]
MSTLLKTTDVRSRIDEQLKAEATSVLQDCGLTISAAIRLFLEQVVQEQRVPFEIKRKQPSLKTTLALKEAKAIEQHYDSI
NEMMVELSKVDSEAK

Nucleotide

• Length: 288 bp

>AT168038 NZ_CP075591:c4822839-4822597 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A345M0A6