Detailed information of TA system TA168037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2911448..2911983
• Replicon: chromosome
• Accession: NZ_CP058958
• Organism: Providencia rettgeri strain G0519

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: H0A34_RS13350
• Protein ID: WP_180312023.1
• Coordinates: 2911675..2911983 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: D4BV21
• Locus tag: H0A34_RS13345
• Protein ID: WP_004255691.1
• Coordinates: 2911448..2911675 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0A34_RS13330	2906817..2907788	+	972	WP_180312022.1	Abi family protein	-
H0A34_RS13335	2907941..2910040	-	2100	WP_004255687.1	flagellar biosynthesis protein FlhA	-
H0A34_RS13340	2910033..2911184	-	1152	WP_140170721.1	flagellar type III secretion system protein FlhB	-
H0A34_RS13345	2911448..2911675	+	228	WP_004255691.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
H0A34_RS13350	2911675..2911983	+	309	WP_180312023.1	CcdB family protein	Toxin
H0A34_RS13355	2911999..2912556	+	558	WP_180312024.1	hypothetical protein	-
H0A34_RS13360	2912599..2912832	-	234	WP_080544466.1	helix-turn-helix domain-containing protein	-
H0A34_RS13365	2913003..2913641	-	639	WP_004255702.1	protein phosphatase CheZ	-
H0A34_RS13370	2913666..2914058	-	393	WP_004255705.1	chemotaxis response regulator CheY	-
H0A34_RS13375	2914100..2915167	-	1068	WP_094961164.1	chemotaxis response regulator protein-glutamate methylesterase	-
H0A34_RS13380	2915167..2916003	-	837	WP_180312668.1	chemotaxis protein-glutamate O-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (5-75)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11847.96 Da
• Isoelectric Point: 6.7057

>T168037 WP_180312023.1 NZ_CP058958:2911675-2911983 [Providencia rettgeri]
MQYCLYQNREDTVKYPYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPVRLNPQLVINEQVFILMTHQMACVPHSLLGKE
IVDLSSQRDTIKHAIDLLIDGF

Nucleotide

• Length: 309 bp

>T168037 NZ_CP075591:c4742337-4741804 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8688.92 Da
• Isoelectric Point: 8.9375

>AT168037 WP_004255691.1 NZ_CP058958:2911448-2911675 [Providencia rettgeri]
MNRTKKTVSVTVAPELYEQARRAKLNLSAILACALQAELKRLEAQKWKNDNVEGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 228 bp

>AT168037 NZ_CP075591:c4742614-4742348 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q922