Detailed information of TA system TA168036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2447734..2448650
• Replicon: chromosome
• Accession: NZ_CP058958
• Organism: Providencia rettgeri strain G0519

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H0A34_RS11145
• Protein ID: WP_144139996.1
• Coordinates: 2448192..2448650 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: D4BTW8
• Locus tag: H0A34_RS11140
• Protein ID: WP_004254502.1
• Coordinates: 2447734..2448195 (+)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0A34_RS11110	2443397..2444011	+	615	WP_004254484.1	LysE family translocator	-
H0A34_RS11115	2444041..2444514	-	474	WP_036957747.1	NUDIX domain-containing protein	-
H0A34_RS11120	2444866..2445507	-	642	WP_004254492.1	leucine efflux protein LeuE	-
H0A34_RS11125	2445978..2446679	+	702	WP_004254495.1	AzlC family ABC transporter permease	-
H0A34_RS11130	2446676..2446990	+	315	WP_094960595.1	AzlD domain-containing protein	-
H0A34_RS11135	2447178..2447645	+	468	WP_094960596.1	DUF1456 family protein	-
H0A34_RS11140	2447734..2448195	+	462	WP_004254502.1	DUF2384 domain-containing protein	Antitoxin
H0A34_RS11145	2448192..2448650	+	459	WP_144139996.1	RES domain-containing protein	Toxin
H0A34_RS11150	2448651..2449541	-	891	WP_180311965.1	LysR family transcriptional regulator	-
H0A34_RS11155	2449587..2450546	-	960	WP_094960599.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
H0A34_RS11160	2450652..2451074	-	423	WP_144139990.1	helix-turn-helix domain-containing protein	-
H0A34_RS11165	2451105..2451668	-	564	WP_004254518.1	GNAT family N-acetyltransferase	-
H0A34_RS11170	2451649..2453115	-	1467	WP_094960601.1	AMP nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17117.65 Da
• Isoelectric Point: 6.4824

>T168036 WP_144139996.1 NZ_CP058958:2448192-2448650 [Providencia rettgeri]
MILYRLVKSNFAHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEVLVHINQDRLLSQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTIWLNNQDSLALLIPSCIVPYEYNAIINPLHPQFQKALHTVKPLDFSVDPRLA

Nucleotide

• Length: 459 bp

>T168036 NZ_CP075591:4132360-4132578 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17090.56 Da
• Isoelectric Point: 9.9140

>AT168036 WP_004254502.1 NZ_CP058958:2447734-2448195 [Providencia rettgeri]
MRNYIPTTPLQPTASSFKPLWRHVGLPAERGIELTHFLRQGLSVSVLDNIQEWSGMSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT168036 NZ_CP075591:4131959-4132333 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A6G6Q7V6