Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1530533..1531190 Replicon chromosome
Accession NZ_CP058958
Organism Providencia rettgeri strain G0519

Toxin (Protein)


Gene name cptA Uniprot ID A0A264VM08
Locus tag H0A34_RS06850 Protein ID WP_036958456.1
Coordinates 1530780..1531190 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D4C097
Locus tag H0A34_RS06845 Protein ID WP_004261864.1
Coordinates 1530533..1530799 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0A34_RS06830 1527529..1528425 - 897 WP_180312516.1 hypothetical protein -
H0A34_RS06835 1528670..1529290 - 621 WP_004261871.1 HD domain-containing protein -
H0A34_RS06840 1529302..1530285 - 984 WP_004261867.1 tRNA-modifying protein YgfZ -
H0A34_RS06845 1530533..1530799 + 267 WP_004261864.1 FAD assembly factor SdhE Antitoxin
H0A34_RS06850 1530780..1531190 + 411 WP_036958456.1 protein YgfX Toxin
H0A34_RS06855 1531290..1531808 - 519 WP_180312517.1 flavodoxin FldB -
H0A34_RS06860 1531926..1532828 + 903 WP_004261814.1 site-specific tyrosine recombinase XerD -
H0A34_RS06865 1532850..1533554 + 705 WP_096863312.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H0A34_RS06870 1533564..1535297 + 1734 WP_094963001.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15568.53 Da        Isoelectric Point: 10.7733

>T168034 WP_036958456.1 NZ_CP058958:1530780-1531190 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLAPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKLHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T168034 NZ_CP075591:1937130-1937232 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10684.24 Da        Isoelectric Point: 4.8942

>AT168034 WP_004261864.1 NZ_CP058958:1530533-1530799 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT168034 NZ_CP075591:c1937239-1937094 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A264VM08

Antitoxin

Source ID Structure
AlphaFold DB A0A345M2Q5

References