Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 855641..856287 Replicon chromosome
Accession NZ_CP058958
Organism Providencia rettgeri strain G0519

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag H0A34_RS03710 Protein ID WP_004905417.1
Coordinates 855641..855844 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D4C184
Locus tag H0A34_RS03715 Protein ID WP_004905413.1
Coordinates 855919..856287 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0A34_RS03685 851717..852055 + 339 WP_004905421.1 P-II family nitrogen regulator -
H0A34_RS03690 852066..853352 + 1287 WP_004905420.1 ammonium transporter AmtB -
H0A34_RS03695 853491..854360 - 870 WP_036958583.1 acyl-CoA thioesterase II -
H0A34_RS03700 854599..855057 + 459 WP_004905418.1 YbaY family lipoprotein -
H0A34_RS03710 855641..855844 - 204 WP_004905417.1 hemolysin expression modulator Hha Toxin
H0A34_RS03715 855919..856287 - 369 WP_004905413.1 Hha toxicity modulator TomB Antitoxin
H0A34_RS03720 856811..858181 - 1371 WP_094962148.1 murein transglycosylase D -
H0A34_RS03725 858263..859018 - 756 WP_004905408.1 hydroxyacylglutathione hydrolase -
H0A34_RS03730 859059..859793 + 735 WP_094962149.1 methyltransferase domain-containing protein -
H0A34_RS03735 859790..860260 - 471 WP_004905405.1 ribonuclease HI -
H0A34_RS03740 860315..861076 + 762 WP_094962150.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T168033 WP_004905417.1 NZ_CP058958:c855844-855641 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T168033 NZ_CP075591:819851-820261 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14085.04 Da        Isoelectric Point: 4.4915

>AT168033 WP_004905413.1 NZ_CP058958:c856287-855919 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNHSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT168033 NZ_CP075591:819604-819870 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6Q6D9

References