Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4117304..4117899 Replicon chromosome
Accession NZ_CP058948
Organism Escherichia coli strain SY3626C5

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag HZ988_RS19980 Protein ID WP_000239577.1
Coordinates 4117304..4117654 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HZ988_RS19985 Protein ID WP_001223208.1
Coordinates 4117648..4117899 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ988_RS19960 4112750..4113772 - 1023 WP_001313531.1 ABC transporter permease -
HZ988_RS19965 4113786..4115288 - 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
HZ988_RS19970 4115428..4116384 - 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HZ988_RS19975 4116694..4117224 + 531 WP_000055075.1 inorganic diphosphatase -
HZ988_RS19980 4117304..4117654 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
HZ988_RS19985 4117648..4117899 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HZ988_RS19990 4118111..4118452 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HZ988_RS19995 4118455..4122234 - 3780 WP_000060911.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T168021 WP_000239577.1 NZ_CP058948:c4117654-4117304 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T168021 NZ_CP075566:c6402897-6402607 [Pseudomonas fluorescens]
ATGGCCGAGCAATTCACCCGTTTCGATGCCGCCGAATTTCTCAAATCGCCAGAAGAAATGGCGGCTTATCTGGATGCATG
CTTTGAAGAAGATGCCGGCGATGGAGTACTGATACGCGCGGCACTCAACGATATAGCCAGAGCACAGGGCATGACACAGG
TTGCACGTGATGCCGGCCTTGGTCGTGAAAGCTTGTACAAAGCATTGAGCAGCACTGGCAATCCGGAATTCGCGACTATC
ATGAAGGTTATGAAAGCCTTGGGTCTGCGTCTGCACGCCACTGCGATCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT168021 WP_001223208.1 NZ_CP058948:c4117899-4117648 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT168021 NZ_CP075566:c6403203-6402901 [Pseudomonas fluorescens]
ATGATCGACTTCGAACGATCCAGCGCATTTGCCGATTGGCTCGACTCAATGAGAGACACCATTGGAAAAGCCCGGATCAT
CGCCAGACTCCGAGCTGCCGAACATGGAAATTTTGGTGATTGCGAACCTGTAGGCGAATCTGTCTATGAAATGCGTGTTC
ATCATGGTCCGGGCTACAGGATGTACTTCACTCGCCGAGGCGAAGTGGTTTACCTGCTTCTGGTGGGGGGCGACAAGTCG
ACTCAAAAACGCGATATCAAACGCGCTATTCAAATGGCGCAAAACATCGGTAATGAGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References