Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2509372..2510203 Replicon chromosome
Accession NZ_CP058948
Organism Escherichia coli strain SY3626C5

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag HZ988_RS12325 Protein ID WP_000854814.1
Coordinates 2509829..2510203 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag HZ988_RS12320 Protein ID WP_001285584.1
Coordinates 2509372..2509740 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ988_RS12305 2507039..2508571 + 1533 WP_001350525.1 hypothetical protein -
HZ988_RS12310 2508568..2509014 + 447 WP_000187523.1 RadC family protein -
HZ988_RS12315 2509077..2509298 + 222 WP_000692323.1 DUF987 domain-containing protein -
HZ988_RS12320 2509372..2509740 + 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
HZ988_RS12325 2509829..2510203 + 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
HZ988_RS12330 2510200..2510394 + 195 WP_000988600.1 hypothetical protein -
HZ988_RS12335 2510407..2510520 + 114 WP_001161660.1 DUF957 domain-containing protein -
HZ988_RS12340 2510809..2510937 - 129 Protein_2416 transposase domain-containing protein -
HZ988_RS12345 2511009..2511191 + 183 WP_001016348.1 hypothetical protein -
HZ988_RS12350 2511292..2511621 - 330 WP_000450409.1 DUF496 family protein -
HZ988_RS12355 2511793..2512851 - 1059 WP_001200891.1 FUSC family protein -
HZ988_RS12360 2513049..2513522 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
HZ988_RS12365 2513641..2514807 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T168012 WP_000854814.1 NZ_CP058948:2509829-2510203 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T168012 NZ_CP075563:1236979-1237155 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT168012 WP_001285584.1 NZ_CP058948:2509372-2509740 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT168012 NZ_CP075563:c1237317-1237143 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References