Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1942322..1942960 Replicon chromosome
Accession NZ_CP058948
Organism Escherichia coli strain SY3626C5

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag HZ988_RS09445 Protein ID WP_000813794.1
Coordinates 1942322..1942498 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZ988_RS09450 Protein ID WP_001270286.1
Coordinates 1942544..1942960 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZ988_RS09425 1937941..1939155 - 1215 WP_001326689.1 BenE family transporter YdcO -
HZ988_RS09430 1939208..1939744 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
HZ988_RS09435 1939817..1941778 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
HZ988_RS09440 1941870..1942100 - 231 WP_000494244.1 YncJ family protein -
HZ988_RS09445 1942322..1942498 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
HZ988_RS09450 1942544..1942960 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
HZ988_RS09455 1943039..1944445 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
HZ988_RS09460 1944690..1945835 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
HZ988_RS09465 1945853..1946866 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
HZ988_RS09470 1946867..1947808 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T168001 WP_000813794.1 NZ_CP058948:1942322-1942498 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T168001 NZ_CP075562:c1715285-1715181 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT168001 WP_001270286.1 NZ_CP058948:1942544-1942960 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT168001 NZ_CP075562:1715087-1715125 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References