Detailed information of TA system TA167976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4507216..4508804
• Replicon: chromosome
• Accession: NZ_CP058940
• Organism: Klebsiella pneumoniae strain BA39649

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486S9S0
• Locus tag: HBJ39_RS22270
• Protein ID: WP_023301940.1
• Coordinates: 4507216..4508538 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HBJ39_RS22275
• Protein ID: WP_002904790.1
• Coordinates: 4508538..4508804 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HBJ39_RS22255 (4502272)	4502272..4504773	+	2502	WP_040182042.1	fimbria/pilus outer membrane usher protein	-
HBJ39_RS22260 (4504761)	4504761..4505765	+	1005	WP_009308876.1	fimbrial protein	-
HBJ39_RS22265 (4505907)	4505907..4507199	+	1293	WP_016946381.1	glycoside hydrolase family 10 protein	-
HBJ39_RS22270 (4507216)	4507216..4508538	-	1323	WP_023301940.1	type II toxin-antitoxin system HipA family toxin	Toxin
HBJ39_RS22275 (4508538)	4508538..4508804	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HBJ39_RS22280 (4509070)	4509070..4509396	-	327	WP_004143476.1	hydroxyisourate hydrolase	-
HBJ39_RS22285 (4509393)	4509393..4509893	-	501	WP_048289870.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HBJ39_RS22290 (4509871)	4509871..4511250	-	1380	WP_004176204.1	nucleobase:cation symporter-2 family protein	-
HBJ39_RS22295 (4511596)	4511596..4512750	+	1155	WP_040182036.1	FAD-dependent urate hydroxylase HpxO	-
HBJ39_RS22300 (4512731)	4512731..4513654	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49185.49 Da
• Isoelectric Point: 7.5358

>T167976 WP_023301940.1 NZ_CP058940:c4508538-4507216 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T167976 NZ_CP075549:52839-53255 [Klebsiella pneumoniae]
GTGAAAAAGACTTTTATGCTCGACACAAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGAGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGCCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT167976 WP_002904790.1 NZ_CP058940:c4508804-4508538 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT167976 NZ_CP075549:52612-52842 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGATTTGACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A486S9S0

Antitoxin

• AlphaFold DB: A0A0H3GXD8