Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2669345..2670002 Replicon chromosome
Accession NZ_CP058940
Organism Klebsiella pneumoniae strain BA39649

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HBJ39_RS13085 Protein ID WP_002916310.1
Coordinates 2669592..2670002 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HBJ39_RS13080 Protein ID WP_002916312.1
Coordinates 2669345..2669611 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ39_RS13055 (2664501) 2664501..2665934 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HBJ39_RS13060 (2666053) 2666053..2666781 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HBJ39_RS13065 (2666831) 2666831..2667142 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HBJ39_RS13070 (2667306) 2667306..2667965 + 660 WP_002916317.1 hemolysin III family protein -
HBJ39_RS13075 (2668116) 2668116..2669099 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
HBJ39_RS13080 (2669345) 2669345..2669611 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HBJ39_RS13085 (2669592) 2669592..2670002 + 411 WP_002916310.1 protein YgfX Toxin
HBJ39_RS13090 (2670009) 2670009..2670530 - 522 WP_004144730.1 flavodoxin FldB -
HBJ39_RS13095 (2670631) 2670631..2671527 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HBJ39_RS13100 (2671550) 2671550..2672263 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HBJ39_RS13105 (2672269) 2672269..2674002 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T167967 WP_002916310.1 NZ_CP058940:2669592-2670002 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T167967 NZ_CP075548:1879258-1879360 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT167967 WP_002916312.1 NZ_CP058940:2669345-2669611 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167967 NZ_CP075548:c1879367-1879222 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References