Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3870467..3870960 Replicon chromosome
Accession NZ_CP058907
Organism Rhodopseudomonas palustris strain CGMCC 1.2180

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HZF03_RS17695 Protein ID WP_119017256.1
Coordinates 3870467..3870661 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HZF03_RS17700 Protein ID WP_119017257.1
Coordinates 3870670..3870960 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZF03_RS17675 3866504..3867037 + 534 WP_119017253.1 thioesterase family protein -
HZF03_RS17680 3867034..3867207 - 174 WP_011159045.1 DUF1328 domain-containing protein -
HZF03_RS17685 3867520..3870066 + 2547 WP_119017254.1 UvrD-helicase domain-containing protein -
HZF03_RS17690 3870066..3870350 + 285 WP_119017255.1 type II toxin-antitoxin system HicB family antitoxin -
HZF03_RS17695 3870467..3870661 + 195 WP_119017256.1 type II toxin-antitoxin system HicA family toxin Toxin
HZF03_RS17700 3870670..3870960 + 291 WP_119017257.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZF03_RS17705 3871256..3872176 + 921 WP_011159048.1 ABC transporter ATP-binding protein -
HZF03_RS17710 3872179..3872940 + 762 WP_011159049.1 ABC transporter permease -
HZF03_RS17715 3873012..3873359 - 348 WP_011159050.1 hypothetical protein -
HZF03_RS17720 3873622..3874392 + 771 WP_011159051.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-80)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7317.48 Da        Isoelectric Point: 10.9446

>T167957 WP_119017256.1 NZ_CP058907:3870467-3870661 [Rhodopseudomonas palustris]
MLTSSRDVIRRLERDGWSCVRVTGSHHVFKHPVRRDIVTVPHPKKDLGKGLVRAIYKGAGWEPD

Download         Length: 195 bp

>T167957 NZ_CP075487:c3614964-3614566 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10480.72 Da        Isoelectric Point: 3.8875

>AT167957 WP_119017257.1 NZ_CP058907:3870670-3870960 [Rhodopseudomonas palustris]
MTHYIAIIEDAGPDVAVGVWFPDLPGCVSAGDDIDDALRNAPEALELYLEQVEQDGRPLPKPRTLTELKADPEVADDIRD
YIVALIETPTRAHAAE

Download         Length: 291 bp

>AT167957 NZ_CP075487:c3615260-3614967 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References