Detailed information of TA system TA167954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2157112..2157782
• Replicon: chromosome
• Accession: NZ_CP058907
• Organism: Rhodopseudomonas palustris strain CGMCC 1.2180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q6N8B2
• Locus tag: HZF03_RS09890
• Protein ID: WP_011157547.1
• Coordinates: 2157112..2157522 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HZF03_RS09895
• Protein ID: WP_011157548.1
• Coordinates: 2157519..2157782 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZF03_RS09875	2153501..2153827	+	327	WP_165858103.1	hypothetical protein	-
HZF03_RS09880	2153994..2155784	+	1791	WP_119017842.1	sulfatase-like hydrolase/transferase	-
HZF03_RS09885	2155820..2156857	+	1038	WP_119017843.1	transporter	-
HZF03_RS09890	2157112..2157522	-	411	WP_011157547.1	type II toxin-antitoxin system VapC family toxin	Toxin
HZF03_RS09895	2157519..2157782	-	264	WP_011157548.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
HZF03_RS09900	2157963..2158388	+	426	WP_012495520.1	cupin domain-containing protein	-
HZF03_RS09905	2158485..2159654	-	1170	WP_119017844.1	DUF2865 domain-containing protein	-
HZF03_RS09910	2159840..2160148	-	309	WP_011157551.1	hypothetical protein	-
HZF03_RS09915	2160554..2161945	+	1392	WP_119017845.1	cysteine--tRNA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (9-58)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15136.48 Da
• Isoelectric Point: 5.6802

>T167954 WP_011157547.1 NZ_CP058907:c2157522-2157112 [Rhodopseudomonas palustris]
MSGWMLDTNVASHVIRGDRREIIERLVALPISDVVISSITEGELLYGLAKRGYPTALSERVREFLLRVDVLPWDHEVTKT
YADLRAVCEAKGVTLSPLDMMIAAHAAATNATLVTRDKAFSRVPSPLRIEDWAEMS

Nucleotide

• Length: 411 bp

>T167954 NZ_CP075487:c2932560-2932183 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9888.91 Da
• Isoelectric Point: 4.7969

>AT167954 WP_011157548.1 NZ_CP058907:c2157782-2157519 [Rhodopseudomonas palustris]
VTSRTAKIFTTGRSQAVRLPAEFRFEGSEVFVRRDPRTGDVILSRKPDSWDGLLQLHQSADVPDDFLGPSDRSQLPQDRD
PFEGWTE

Nucleotide

• Length: 264 bp

>AT167954 NZ_CP075487:c2933018-2932650 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCAGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: Q6N8B2