Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2242940..2243466 | Replicon | chromosome |
| Accession | NZ_CP058886 | ||
| Organism | Shigella flexneri strain STLEFF_33 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | HZT25_RS10935 | Protein ID | WP_000323025.1 |
| Coordinates | 2243179..2243466 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | HZT25_RS10930 | Protein ID | WP_000534858.1 |
| Coordinates | 2242940..2243179 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT25_RS10900 (2238668) | 2238668..2238898 | - | 231 | Protein_2139 | IS66 family insertion sequence element accessory protein TnpB | - |
| HZT25_RS10905 (2238904) | 2238904..2239026 | - | 123 | Protein_2140 | transposase | - |
| HZT25_RS10910 (2239269) | 2239269..2239690 | + | 422 | Protein_2141 | hypothetical protein | - |
| HZT25_RS10915 (2240325) | 2240325..2241638 | + | 1314 | WP_000589005.1 | ISNCY family transposase | - |
| HZT25_RS10920 (2242075) | 2242075..2242407 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| HZT25_RS10925 (2242610) | 2242610..2242915 | - | 306 | WP_001326990.1 | protein YdfV | - |
| HZT25_RS10930 (2242940) | 2242940..2243179 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| HZT25_RS10935 (2243179) | 2243179..2243466 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| HZT25_RS10940 (2243538) | 2243538..2243693 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| HZT25_RS10945 (2243910) | 2243910..2244161 | + | 252 | WP_000980994.1 | protein Rem | - |
| HZT25_RS10950 (2244228) | 2244228..2244506 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| HZT25_RS10955 (2244508) | 2244508..2245557 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| HZT25_RS10960 (2245571) | 2245571..2246323 | + | 753 | WP_001047135.1 | antitermination protein | - |
| HZT25_RS10965 (2246601) | 2246601..2246690 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| HZT25_RS10970 (2246745) | 2246745..2246957 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| HZT25_RS10975 (2247258) | 2247258..2247473 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| HZT25_RS10980 (2247837) | 2247837..2248007 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| HZT25_RS10985 (2248227) | 2248227..2248442 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2220400..2258654 | 38254 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T167939 WP_000323025.1 NZ_CP058886:2243179-2243466 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T167939 NZ_CP075484:c4473510-4473199 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT167939 WP_000534858.1 NZ_CP058886:2242940-2243179 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT167939 NZ_CP075484:c4473198-4472908 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|