Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 46422..47023 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP058881 | ||
| Organism | Escherichia coli strain STLEFF_29 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | HZT24_RS24410 | Protein ID | WP_121855399.1 |
| Coordinates | 46422..46802 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | HZT24_RS24415 | Protein ID | WP_001190712.1 |
| Coordinates | 46802..47023 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT24_RS24385 (HZT24_24265) | 41863..43305 | - | 1443 | WP_001472843.1 | hypothetical protein | - |
| HZT24_RS24390 (HZT24_24270) | 43347..44540 | - | 1194 | WP_032153803.1 | hypothetical protein | - |
| HZT24_RS24395 (HZT24_24275) | 44626..45078 | - | 453 | WP_001326849.1 | late promoter-activating protein | - |
| HZT24_RS24400 (HZT24_24280) | 45167..46210 | - | 1044 | WP_208557430.1 | DUF968 domain-containing protein | - |
| HZT24_RS24405 (HZT24_24285) | 46238..46417 | - | 180 | WP_000113018.1 | hypothetical protein | - |
| HZT24_RS24410 (HZT24_24290) | 46422..46802 | - | 381 | WP_121855399.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| HZT24_RS24415 (HZT24_24295) | 46802..47023 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| HZT24_RS24420 (HZT24_24300) | 47096..47485 | - | 390 | WP_000506730.1 | S24 family peptidase | - |
| HZT24_RS24425 (HZT24_24305) | 47660..48244 | + | 585 | WP_032272826.1 | hypothetical protein | - |
| HZT24_RS24430 (HZT24_24310) | 48245..48601 | + | 357 | WP_032272825.1 | hypothetical protein | - |
| HZT24_RS24435 (HZT24_24315) | 49677..50039 | - | 363 | WP_001261543.1 | hypothetical protein | - |
| HZT24_RS24440 (HZT24_24320) | 50036..50935 | - | 900 | WP_233403841.1 | hypothetical protein | - |
| HZT24_RS24445 | 50912..51046 | - | 135 | Protein_53 | hypothetical protein | - |
| HZT24_RS24450 (HZT24_24325) | 51380..51558 | - | 179 | Protein_54 | hypothetical protein | - |
| HZT24_RS24455 (HZT24_24330) | 51560..51748 | - | 189 | WP_000797279.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..96770 | 96770 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13621.28 Da Isoelectric Point: 5.1514
>T167920 WP_121855399.1 NZ_CP058881:c46802-46422 [Escherichia coli]
MRHISPEELIALHDANINRYGGLPGMSDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSSE
MRHISPEELIALHDANINRYGGLPGMSDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSSE
Download Length: 381 bp
>T167920 NZ_CP075484:c595665-595201 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT167920 WP_001190712.1 NZ_CP058881:c47023-46802 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT167920 NZ_CP075484:c596000-595665 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|