Detailed information of TA system TA167911

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 4263827..4264422
• Replicon: chromosome
• Accession: NZ_CP058879
• Organism: Escherichia coli strain STLEFF_29

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: V0SXT4
• Locus tag: HZT24_RS20505
• Protein ID: WP_000239581.1
• Coordinates: 4263827..4264177 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: L4JJX7
• Locus tag: HZT24_RS20510
• Protein ID: WP_001223213.1
• Coordinates: 4264171..4264422 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT24_RS20485 (4259281)	4259281..4260303	-	1023	WP_001361374.1	ABC transporter permease	-
HZT24_RS20490 (4260317)	4260317..4261819	-	1503	WP_001095661.1	ATP-binding cassette domain-containing protein	-
HZT24_RS20495 (4261952)	4261952..4262908	-	957	WP_108997067.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
HZT24_RS20500 (4263218)	4263218..4263748	+	531	WP_000055072.1	inorganic diphosphatase	-
HZT24_RS20505 (4263827)	4263827..4264177	-	351	WP_000239581.1	endoribonuclease toxin ChpB	Toxin
HZT24_RS20510 (4264171)	4264171..4264422	-	252	WP_001223213.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
HZT24_RS20515 (4264634)	4264634..4264975	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
HZT24_RS20520 (4264978)	4264978..4268757	-	3780	WP_108997070.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12453.41 Da
• Isoelectric Point: 6.2206

>T167911 WP_000239581.1 NZ_CP058879:c4264177-4263827 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T167911 NZ_CP075480:3394564-3394782 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9331.64 Da
• Isoelectric Point: 4.6509

>AT167911 WP_001223213.1 NZ_CP058879:c4264422-4264171 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT167911 NZ_CP075480:3394164-3394538 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: V0SXT4

Antitoxin

• AlphaFold DB: L4JJX7