167908

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3662310..3663147 Replicon chromosome
Accession NZ_CP058879
Organism Escherichia coli strain STLEFF_29

Toxin (Protein)


Gene name itaT Uniprot ID A0A1M0D5U3
Locus tag HZT24_RS17655 Protein ID WP_000227782.1
Coordinates 3662605..3663147 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID B1LJI1
Locus tag HZT24_RS17650 Protein ID WP_001353405.1
Coordinates 3662310..3662621 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT24_RS17625 (3657330) 3657330..3658277 + 948 WP_001239437.1 cytochrome o ubiquinol oxidase subunit II -
HZT24_RS17630 (3658299) 3658299..3660290 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
HZT24_RS17635 (3660280) 3660280..3660894 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
HZT24_RS17640 (3660894) 3660894..3661223 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
HZT24_RS17645 (3661235) 3661235..3662125 + 891 WP_000971327.1 heme o synthase -
HZT24_RS17650 (3662310) 3662310..3662621 + 312 WP_001353405.1 DUF1778 domain-containing protein Antitoxin
HZT24_RS17655 (3662605) 3662605..3663147 + 543 WP_000227782.1 GNAT family N-acetyltransferase Toxin
HZT24_RS17660 (3663203) 3663203..3664047 - 845 Protein_3470 tetratricopeptide repeat protein -
HZT24_RS17665 (3664454) 3664454..3665818 + 1365 WP_001000978.1 MFS transporter -
HZT24_RS17670 (3665946) 3665946..3666437 - 492 WP_001138904.1 nucleotide binding protein YajQ -
HZT24_RS17675 (3666605) 3666605..3667516 + 912 WP_000705841.1 2-dehydropantoate 2-reductase -
HZT24_RS17680 (3667479) 3667479..3668069 + 591 WP_001276320.1 protein deglycase YajL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19957.31 Da        Isoelectric Point: 9.1763

>T167908 WP_000227782.1 NZ_CP058879:3662605-3663147 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDIIYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCNFFEHVKIIHRALPIKGVYLDADPAAINFYTRLGFVQLSA
RPNVFGAVPMFLAIQHILAA

Download         Length: 543 bp

>T167908 NZ_CP075480:2595473-2595580 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11370.09 Da        Isoelectric Point: 10.4825

>AT167908 WP_001353405.1 NZ_CP058879:3662310-3662621 [Escherichia coli]
MPGKTVALPDIDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT167908 NZ_CP075480:c2595426-2595360 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0D5U3

Antitoxin

Source ID Structure
AlphaFold DB A0A829G7G3

References