Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3628220..3628838 Replicon chromosome
Accession NZ_CP058879
Organism Escherichia coli strain STLEFF_29

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT24_RS17485 Protein ID WP_001291435.1
Coordinates 3628620..3628838 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag HZT24_RS17480 Protein ID WP_000344800.1
Coordinates 3628220..3628594 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT24_RS17470 (3623309) 3623309..3624502 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT24_RS17475 (3624525) 3624525..3627674 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT24_RS17480 (3628220) 3628220..3628594 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
HZT24_RS17485 (3628620) 3628620..3628838 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT24_RS17490 (3629010) 3629010..3629561 + 552 WP_000102574.1 maltose O-acetyltransferase -
HZT24_RS17495 (3629677) 3629677..3630147 + 471 WP_000136192.1 YlaC family protein -
HZT24_RS17500 (3630311) 3630311..3631861 + 1551 WP_001361689.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT24_RS17505 (3631903) 3631903..3632256 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZT24_RS17515 (3632635) 3632635..3632946 + 312 WP_000409911.1 MGMT family protein -
HZT24_RS17520 (3632977) 3632977..3633549 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167907 WP_001291435.1 NZ_CP058879:3628620-3628838 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167907 NZ_CP075480:2594938-2595045 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT167907 WP_000344800.1 NZ_CP058879:3628220-3628594 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167907 NZ_CP075480:c2594891-2594825 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References