Detailed information of TA system TA167905

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-HTH_XRE
• Location: 3204478..3205183
• Replicon: chromosome
• Accession: NZ_CP058879
• Organism: Escherichia coli strain STLEFF_29

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1M2J6W7
• Locus tag: HZT24_RS15365
• Protein ID: WP_000539524.1
• Coordinates: 3204478..3204864 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZT24_RS15370
• Protein ID: WP_001280945.1
• Coordinates: 3204854..3205183 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT24_RS15345 (3200482)	3200482..3201108	+	627	WP_001295292.1	glutathione S-transferase GstB	-
HZT24_RS15350 (3201105)	3201105..3202220	-	1116	WP_000555056.1	aldose sugar dehydrogenase YliI	-
HZT24_RS15355 (3202331)	3202331..3202714	-	384	WP_000497137.1	biofilm formation regulator BssR	-
HZT24_RS15360 (3202927)	3202927..3204252	+	1326	WP_000049367.1	30S ribosomal protein S12 methylthiotransferase RimO	-
HZT24_RS15365 (3204478)	3204478..3204864	+	387	WP_000539524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZT24_RS15370 (3204854)	3204854..3205183	+	330	WP_001280945.1	DNA-binding transcriptional regulator	Antitoxin
HZT24_RS15375 (3205253)	3205253..3206570	-	1318	Protein_3029	diguanylate cyclase	-
HZT24_RS15380 (3206578)	3206578..3208926	-	2349	WP_000950331.1	EAL domain-containing protein	-
HZT24_RS15385 (3209103)	3209103..3210014	-	912	WP_001236044.1	glutathione ABC transporter permease GsiD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-124)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-94)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14321.46 Da
• Isoelectric Point: 9.9521

>T167905 WP_000539524.1 NZ_CP058879:3204478-3204864 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSRSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Nucleotide

• Length: 387 bp

>T167905 NZ_CP075480:2232773-2233060 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11982.08 Da
• Isoelectric Point: 10.0101

>AT167905 WP_001280945.1 NZ_CP058879:3204854-3205183 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Nucleotide

• Length: 330 bp

>AT167905 NZ_CP075480:2232534-2232773 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: A0A1M2J6W7