Detailed information of TA system TA167892

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 872239..873071
• Replicon: chromosome
• Accession: NZ_CP058879
• Organism: Escherichia coli strain STLEFF_29

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A3P5UBZ5
• Locus tag: HZT24_RS04205
• Protein ID: WP_001094454.1
• Coordinates: 872239..872613 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A3G8RJV8
• Locus tag: HZT24_RS04210
• Protein ID: WP_001320394.1
• Coordinates: 872703..873071 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT24_RS04175 (867352)	867352..868500	-	1149	WP_000905922.1	capsule polysaccharide export inner-membrane protein KpsE	-
HZT24_RS04180 (868572)	868572..869555	-	984	WP_001298261.1	KpsF/GutQ family sugar-phosphate isomerase	-
HZT24_RS04185 (870366)	870366..870536	-	171	Protein_824	IS110 family transposase	-
HZT24_RS04190 (870879)	870879..871448	-	570	WP_001290250.1	DUF4942 domain-containing protein	-
HZT24_RS04195 (871545)	871545..871742	-	198	WP_000839276.1	DUF957 domain-containing protein	-
HZT24_RS04200 (871754)	871754..872242	-	489	WP_000777545.1	DUF5983 family protein	-
HZT24_RS04205 (872239)	872239..872613	-	375	WP_001094454.1	TA system toxin CbtA family protein	Toxin
HZT24_RS04210 (872703)	872703..873071	-	369	WP_001320394.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
HZT24_RS04215 (873121)	873121..873764	-	644	Protein_830	antitoxin of toxin-antitoxin stability system	-
HZT24_RS04220 (873783)	873783..874004	-	222	WP_000692300.1	DUF987 domain-containing protein	-
HZT24_RS04225 (874067)	874067..874543	-	477	WP_001347688.1	RadC family protein	-
HZT24_RS04230 (874559)	874559..875044	-	486	WP_029701480.1	antirestriction protein	-
HZT24_RS04235 (875099)	875099..875917	-	819	WP_001234642.1	DUF932 domain-containing protein	-
HZT24_RS04240 (876017)	876017..876250	-	234	WP_001119719.1	DUF905 family protein	-
HZT24_RS04245 (876329)	876329..876784	-	456	WP_000581493.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14059.10 Da
• Isoelectric Point: 9.2447

>T167892 WP_001094454.1 NZ_CP058879:c872613-872239 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Nucleotide

• Length: 375 bp

>T167892 NZ_CP075477:c4192807-4192634 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13623.22 Da
• Isoelectric Point: 6.4783

>AT167892 WP_001320394.1 NZ_CP058879:c873071-872703 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Nucleotide

• Length: 369 bp

>AT167892 NZ_CP075477:c4193131-4192835 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A3P5UBZ5

Antitoxin

• AlphaFold DB: A0A3G8RJV8