Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3941771..3942569 Replicon chromosome
Accession NZ_CP058874
Organism Escherichia coli strain STLEFF_47

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag HZT32_RS19180 Protein ID WP_000854730.1
Coordinates 3942192..3942569 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag HZT32_RS19175 Protein ID WP_001285481.1
Coordinates 3941771..3942145 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT32_RS19135 (3937746) 3937746..3938198 + 453 WP_000682723.1 hypothetical protein -
HZT32_RS19140 (3938316) 3938316..3938549 + 234 WP_001213776.1 DUF905 family protein -
HZT32_RS19145 (3938649) 3938649..3939470 + 822 WP_001234359.1 DUF932 domain-containing protein -
HZT32_RS19150 (3939470) 3939470..3939715 + 246 WP_001164966.1 hypothetical protein -
HZT32_RS19155 (3939809) 3939809..3940282 + 474 WP_001313575.1 antirestriction protein -
HZT32_RS19160 (3940298) 3940298..3940774 + 477 WP_001313574.1 RadC family protein -
HZT32_RS19165 (3940837) 3940837..3941058 + 222 WP_000692315.1 DUF987 domain-containing protein -
HZT32_RS19170 (3941077) 3941077..3941721 + 645 WP_000086759.1 hypothetical protein -
HZT32_RS19175 (3941771) 3941771..3942145 + 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT32_RS19180 (3942192) 3942192..3942569 + 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
HZT32_RS19185 (3942566) 3942566..3943058 + 493 Protein_3769 DUF5983 family protein -
HZT32_RS19190 (3943137) 3943137..3944125 - 989 Protein_3770 IS630 family transposase -
HZT32_RS19195 (3944273) 3944273..3945866 - 1594 Protein_3771 IS66 family transposase -
HZT32_RS19200 (3945897) 3945897..3946247 - 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
HZT32_RS19205 (3946244) 3946244..3946535 - 292 Protein_3773 transposase -
HZT32_RS19210 (3946577) 3946577..3946771 + 195 WP_001313570.1 DUF957 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3895300..3950811 55511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T167866 WP_000854730.1 NZ_CP058874:3942192-3942569 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T167866 NZ_CP075474:c2956180-2955803 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTATTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGCC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT167866 WP_001285481.1 NZ_CP058874:3941771-3942145 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT167866 NZ_CP075474:c2956401-2956180 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGTCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTCGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References