Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3577913..3578531 Replicon chromosome
Accession NZ_CP058874
Organism Escherichia coli strain STLEFF_47

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag HZT32_RS17470 Protein ID WP_001291435.1
Coordinates 3578313..3578531 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8S7S0Y3
Locus tag HZT32_RS17465 Protein ID WP_039004128.1
Coordinates 3577913..3578287 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT32_RS17455 (3573002) 3573002..3574195 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT32_RS17460 (3574218) 3574218..3577367 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
HZT32_RS17465 (3577913) 3577913..3578287 + 375 WP_039004128.1 Hha toxicity modulator TomB Antitoxin
HZT32_RS17470 (3578313) 3578313..3578531 + 219 WP_001291435.1 HHA domain-containing protein Toxin
HZT32_RS17475 (3578703) 3578703..3579254 + 552 WP_000102564.1 maltose O-acetyltransferase -
HZT32_RS17480 (3579370) 3579370..3579840 + 471 WP_000136192.1 YlaC family protein -
HZT32_RS17485 (3580004) 3580004..3581554 + 1551 WP_001317659.1 cyclic-guanylate-specific phosphodiesterase PdeB -
HZT32_RS17490 (3581596) 3581596..3581949 - 354 WP_000878140.1 DUF1428 domain-containing protein -
HZT32_RS17500 (3582328) 3582328..3582639 + 312 WP_000409911.1 MGMT family protein -
HZT32_RS17505 (3582670) 3582670..3583242 - 573 WP_000779821.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167865 WP_001291435.1 NZ_CP058874:3578313-3578531 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T167865 NZ_CP075474:c2932558-2932181 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT167865 WP_039004128.1 NZ_CP058874:3577913-3578287 [Escherichia coli]
MDEYSPKRHDITQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT167865 NZ_CP075474:c2933016-2932648 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCAGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References