Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3165351..3166056 Replicon chromosome
Accession NZ_CP058874
Organism Escherichia coli strain STLEFF_47

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag HZT32_RS15350 Protein ID WP_000539521.1
Coordinates 3165351..3165737 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HZT32_RS15355 Protein ID WP_001280945.1
Coordinates 3165727..3166056 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT32_RS15330 (3161355) 3161355..3161981 + 627 WP_001295292.1 glutathione S-transferase GstB -
HZT32_RS15335 (3161978) 3161978..3163093 - 1116 WP_000555041.1 aldose sugar dehydrogenase YliI -
HZT32_RS15340 (3163204) 3163204..3163587 - 384 WP_000497137.1 biofilm formation regulator BssR -
HZT32_RS15345 (3163800) 3163800..3165125 + 1326 WP_000049378.1 30S ribosomal protein S12 methylthiotransferase RimO -
HZT32_RS15350 (3165351) 3165351..3165737 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT32_RS15355 (3165727) 3165727..3166056 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
HZT32_RS15360 (3166126) 3166126..3167454 - 1329 WP_000086919.1 GGDEF domain-containing protein -
HZT32_RS15365 (3167462) 3167462..3169810 - 2349 Protein_3020 EAL domain-containing protein -
HZT32_RS15370 (3169988) 3169988..3170899 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T167863 WP_000539521.1 NZ_CP058874:3165351-3165737 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T167863 NZ_CP075474:2595779-2595886 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT167863 WP_001280945.1 NZ_CP058874:3165727-3166056 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT167863 NZ_CP075474:c2595732-2595666 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References