Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 134250..135001 Replicon plasmid unnamed1
Accession NZ_CP058870
Organism Klebsiella pneumoniae strain STLEFF_44

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag HZT31_RS26285 Protein ID WP_014386536.1
Coordinates 134250..134732 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag HZT31_RS26290 Protein ID WP_004902250.1
Coordinates 134723..135001 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT31_RS26265 (HZT31_26210) 130649..131296 - 648 WP_014386537.1 EcsC family protein -
HZT31_RS26270 (HZT31_26215) 131323..132078 - 756 WP_004902235.1 DUF2971 domain-containing protein -
HZT31_RS26275 (HZT31_26220) 132179..132571 - 393 WP_032442757.1 hypothetical protein -
HZT31_RS26280 (HZT31_26225) 132676..133215 - 540 WP_004902239.1 hypothetical protein -
HZT31_RS26285 (HZT31_26230) 134250..134732 - 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
HZT31_RS26290 (HZT31_26235) 134723..135001 - 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
HZT31_RS26295 (HZT31_26240) 135120..135332 - 213 WP_004902255.1 hypothetical protein -
HZT31_RS26300 (HZT31_26245) 135440..135781 - 342 WP_004902257.1 hypothetical protein -
HZT31_RS26305 (HZT31_26250) 136611..137069 - 459 WP_014386535.1 hypothetical protein -
HZT31_RS26310 (HZT31_26255) 137722..138177 - 456 WP_001166628.1 Hg(II)-responsive transcriptional regulator -
HZT31_RS26315 (HZT31_26260) 138249..138614 + 366 WP_001294656.1 mercuric ion transporter MerT -
HZT31_RS26320 (HZT31_26265) 138630..138905 + 276 WP_000732275.1 mercury resistance system periplasmic binding protein MerP -
HZT31_RS26325 (HZT31_26270) 138933..139358 + 426 WP_000522996.1 organomercurial transporter MerC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId - 1..283086 283086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T167837 WP_014386536.1 NZ_CP058870:c134732-134250 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

>T167837 NZ_CP075472:c1062823-1062440 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT167837 WP_004902250.1 NZ_CP058870:c135001-134723 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT167837 NZ_CP075472:c1063281-1062913 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References