Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 55508..56418 Replicon plasmid unnamed1
Accession NZ_CP058870
Organism Klebsiella pneumoniae strain STLEFF_44

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag HZT31_RS25905 Protein ID WP_004026354.1
Coordinates 55948..56418 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag HZT31_RS25900 Protein ID WP_004181895.1
Coordinates 55508..55951 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT31_RS25885 (HZT31_25830) 52141..53628 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -
HZT31_RS25890 (HZT31_25835) 53714..54136 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
HZT31_RS25895 (HZT31_25840) 54136..55407 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
HZT31_RS25900 (HZT31_25845) 55508..55951 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
HZT31_RS25905 (HZT31_25850) 55948..56418 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
HZT31_RS25910 (HZT31_25855) 56528..56788 - 261 WP_004026352.1 hypothetical protein -
HZT31_RS25915 (HZT31_25860) 57360..58541 - 1182 WP_004883380.1 IS481 family transposase -
HZT31_RS25920 (HZT31_25865) 58613..58771 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
HZT31_RS25925 (HZT31_25870) 59374..60348 + 975 WP_014386572.1 hypothetical protein -
HZT31_RS25930 (HZT31_25875) 60546..60923 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(B) / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / aac(3)-IId - 1..283086 283086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T167836 WP_004026354.1 NZ_CP058870:55948-56418 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T167836 NZ_CP075472:942465-942800 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT167836 WP_004181895.1 NZ_CP058870:55508-55951 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT167836 NZ_CP075472:942217-942465 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References