Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3957829..3958448 Replicon chromosome
Accession NZ_CP058869
Organism Klebsiella pneumoniae strain STLEFF_44

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZT31_RS19515 Protein ID WP_002892050.1
Coordinates 3958230..3958448 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZT31_RS19510 Protein ID WP_002892066.1
Coordinates 3957829..3958203 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT31_RS19500 (3952981) 3952981..3954174 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT31_RS19505 (3954197) 3954197..3957343 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZT31_RS19510 (3957829) 3957829..3958203 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZT31_RS19515 (3958230) 3958230..3958448 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZT31_RS19520 (3958611) 3958611..3959177 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZT31_RS19525 (3959149) 3959149..3959289 - 141 WP_004147370.1 hypothetical protein -
HZT31_RS19530 (3959310) 3959310..3959780 + 471 WP_002892026.1 YlaC family protein -
HZT31_RS19535 (3959755) 3959755..3961206 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
HZT31_RS19540 (3961307) 3961307..3962005 + 699 WP_002892021.1 GNAT family protein -
HZT31_RS19545 (3962002) 3962002..3962142 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZT31_RS19550 (3962142) 3962142..3962405 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167831 WP_002892050.1 NZ_CP058869:3958230-3958448 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167831 NZ_CP075471:c59630-59349 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167831 WP_002892066.1 NZ_CP058869:3957829-3958203 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167831 NZ_CP075471:c59871-59620 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References