Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 681284..681963 Replicon chromosome
Accession NZ_CP058869
Organism Klebsiella pneumoniae strain STLEFF_44

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag HZT31_RS03345 Protein ID WP_020324801.1
Coordinates 681622..681963 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag HZT31_RS03340 Protein ID WP_020324792.1
Coordinates 681284..681601 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT31_RS03315 (676498) 676498..679650 + 3153 WP_022631414.1 AIDA repeat-containing protein -
HZT31_RS03320 (679743) 679743..679982 + 240 WP_020324820.1 DUF905 domain-containing protein -
HZT31_RS03325 (680085) 680085..680543 + 459 WP_020324813.1 antirestriction protein -
HZT31_RS03330 (680559) 680559..681035 + 477 WP_020324797.1 RadC family protein -
HZT31_RS03335 (681044) 681044..681271 + 228 WP_020324796.1 DUF987 domain-containing protein -
HZT31_RS03340 (681284) 681284..681601 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT31_RS03345 (681622) 681622..681963 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
HZT31_RS03350 (682079) 682079..682912 + 834 WP_020324805.1 DUF4942 domain-containing protein -
HZT31_RS03360 (683215) 683215..683721 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
HZT31_RS03365 (683821) 683821..685662 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 649827..682912 33085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T167820 WP_020324801.1 NZ_CP058869:681622-681963 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T167820 NZ_CP075469:2057436-2057539 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT167820 WP_020324792.1 NZ_CP058869:681284-681601 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT167820 NZ_CP075469:c2057577-2057306 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References