Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4772819..4773335 Replicon chromosome
Accession NZ_CP058866
Organism Klebsiella pneumoniae strain STLEFF_42

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag HZT30_RS23235 Protein ID WP_004178374.1
Coordinates 4772819..4773103 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HZT30_RS23240 Protein ID WP_002886901.1
Coordinates 4773093..4773335 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT30_RS23210 (4768303) 4768303..4768566 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
HZT30_RS23215 (4768696) 4768696..4768869 + 174 WP_032408826.1 hypothetical protein -
HZT30_RS23220 (4768872) 4768872..4769615 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HZT30_RS23225 (4769972) 4769972..4772110 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HZT30_RS23230 (4772351) 4772351..4772815 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZT30_RS23235 (4772819) 4772819..4773103 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT30_RS23240 (4773093) 4773093..4773335 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZT30_RS23245 (4773413) 4773413..4775323 - 1911 WP_004178373.1 PRD domain-containing protein -
HZT30_RS23250 (4775346) 4775346..4776500 - 1155 WP_004178372.1 lactonase family protein -
HZT30_RS23255 (4776567) 4776567..4777307 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T167814 WP_004178374.1 NZ_CP058866:c4773103-4772819 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T167814 NZ_CP075469:c629486-629022 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT167814 WP_002886901.1 NZ_CP058866:c4773335-4773093 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT167814 NZ_CP075469:c629821-629486 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References