Detailed information of TA system TA167795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4696704..4697217
• Replicon: chromosome
• Accession: NZ_CP058859
• Organism: Klebsiella quasipneumoniae strain STLEFF_28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8H9ZM07
• Locus tag: HZT23_RS22820
• Protein ID: WP_049092408.1
• Coordinates: 4696704..4696985 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HZT23_RS22825
• Protein ID: WP_101839288.1
• Coordinates: 4696975..4697217 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT23_RS22805 (4691746)	4691746..4693401	+	1656	WP_049003742.1	alpha,alpha-phosphotrehalase	-
HZT23_RS22810 (4693787)	4693787..4695925	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
HZT23_RS22815 (4696236)	4696236..4696700	+	465	WP_119620834.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
HZT23_RS22820 (4696704)	4696704..4696985	-	282	WP_049092408.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HZT23_RS22825 (4696975)	4696975..4697217	-	243	WP_101839288.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HZT23_RS22830 (4697295)	4697295..4699205	-	1911	WP_050533672.1	PRD domain-containing protein	-
HZT23_RS22835 (4699228)	4699228..4700382	-	1155	WP_119620835.1	lactonase family protein	-
HZT23_RS22840 (4700545)	4700545..4701285	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (17-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11034.84 Da
• Isoelectric Point: 10.3681

>T167795 WP_049092408.1 NZ_CP058859:c4696985-4696704 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCDKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T167795 NZ_CP075465:747759-748055 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9075.57 Da
• Isoelectric Point: 6.3340

>AT167795 WP_101839288.1 NZ_CP058859:c4697217-4696975 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT167795 NZ_CP075465:748057-748452 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA