Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4595712..4596500 Replicon chromosome
Accession NZ_CP058859
Organism Klebsiella quasipneumoniae strain STLEFF_28

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag HZT23_RS22325 Protein ID WP_240708857.1
Coordinates 4595712..4596089 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag HZT23_RS22330 Protein ID WP_047684017.1
Coordinates 4596141..4596500 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT23_RS22295 (4591148) 4591148..4591786 - 639 WP_240708851.1 HNH endonuclease -
HZT23_RS22300 (4591966) 4591966..4592835 + 870 WP_240708853.1 HNH endonuclease -
HZT23_RS22305 (4593141) 4593141..4593938 - 798 WP_047684029.1 helix-turn-helix transcriptional regulator -
HZT23_RS22310 (4594082) 4594082..4594927 - 846 WP_047684026.1 DUF4942 domain-containing protein -
HZT23_RS22315 (4595009) 4595009..4595194 - 186 WP_047684023.1 DUF957 domain-containing protein -
HZT23_RS22320 (4595224) 4595224..4595715 - 492 WP_240708855.1 DUF5983 family protein -
HZT23_RS22325 (4595712) 4595712..4596089 - 378 WP_240708857.1 TA system toxin CbtA family protein Toxin
HZT23_RS22330 (4596141) 4596141..4596500 - 360 WP_047684017.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
HZT23_RS22335 (4596523) 4596523..4596744 - 222 WP_040246532.1 DUF987 domain-containing protein -
HZT23_RS22340 (4596765) 4596765..4597244 - 480 WP_040246529.1 DNA repair protein RadC -
HZT23_RS22345 (4597256) 4597256..4597726 - 471 WP_134897158.1 antirestriction protein -
HZT23_RS22350 (4597966) 4597966..4598163 - 198 WP_224331357.1 DUF905 family protein -
HZT23_RS22355 (4598213) 4598213..4598434 - 222 WP_240708860.1 hypothetical protein -
HZT23_RS22360 (4598508) 4598508..4598978 - 471 WP_094963531.1 hypothetical protein -
HZT23_RS22365 (4599030) 4599030..4599341 - 312 WP_047684007.1 hypothetical protein -
HZT23_RS22370 (4599399) 4599399..4599701 - 303 WP_047684004.1 hypothetical protein -
HZT23_RS22375 (4599734) 4599734..4600171 - 438 WP_052141301.1 hypothetical protein -
HZT23_RS22380 (4600185) 4600185..4600895 - 711 WP_047684001.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14025.72 Da        Isoelectric Point: 5.5540

>T167793 WP_240708857.1 NZ_CP058859:c4596089-4595712 [Klebsiella quasipneumoniae]
MQTQPLSSTQEASPRPSQVDIWQQLLSHLLDRHYGLTLNDTPFGHDGVIQEHIDAGISLCDAVNVIVEKYDLVRTDRPGF
SAETQSTLISSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

>T167793 NZ_CP075465:641064-641378 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13061.82 Da        Isoelectric Point: 5.4250

>AT167793 WP_047684017.1 NZ_CP058859:c4596500-4596141 [Klebsiella quasipneumoniae]
MSNEIPAVNHDIAEPWWGLKPTVTPCFGARLVQEGNQVHYLADRASITGQFSEADLRHLDQAFPVLLKQLELMLVSGELN
PHHQHGVTLYAKGLTCEADSLGSYGYIYIAIYPTPAATA

Download         Length: 360 bp

>AT167793 NZ_CP075465:641375-641791 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References