Detailed information of TA system TA167790

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2503469..2505057
• Replicon: chromosome
• Accession: NZ_CP058859
• Organism: Klebsiella quasipneumoniae strain STLEFF_28

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: HZT23_RS12180
• Protein ID: WP_032456033.1
• Coordinates: 2503469..2504791 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A2A5MFC9
• Locus tag: HZT23_RS12185
• Protein ID: WP_004205921.1
• Coordinates: 2504791..2505057 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT23_RS12145 (2498551)	2498551..2498769	+	219	WP_002904808.1	ParD-like family protein	-
HZT23_RS12150 (2498750)	2498750..2499532	+	783	WP_049003659.1	type I methionyl aminopeptidase	-
HZT23_RS12155 (2499801)	2499801..2500916	+	1116	WP_109882623.1	serine hydrolase domain-containing protein	-
HZT23_RS12160 (2500903)	2500903..2501247	+	345	WP_004205915.1	hypothetical protein	-
HZT23_RS12165 (2501276)	2501276..2501809	+	534	WP_004205916.1	hypothetical protein	-
HZT23_RS12170 (2501812)	2501812..2502018	+	207	WP_004205917.1	helix-turn-helix transcriptional regulator	-
HZT23_RS12175 (2502160)	2502160..2503452	+	1293	WP_099441800.1	glycoside hydrolase family 10 protein	-
HZT23_RS12180 (2503469)	2503469..2504791	-	1323	WP_032456033.1	type II toxin-antitoxin system HipA family toxin	Toxin
HZT23_RS12185 (2504791)	2504791..2505057	-	267	WP_004205921.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HZT23_RS12190 (2505340)	2505340..2505666	-	327	WP_017900379.1	hydroxyisourate hydrolase	-
HZT23_RS12195 (2505663)	2505663..2506163	-	501	WP_017900378.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HZT23_RS12200 (2506141)	2506141..2507520	-	1380	WP_017900377.1	nucleobase:cation symporter-2 family protein	-
HZT23_RS12205 (2507866)	2507866..2509020	+	1155	WP_004205928.1	FAD-dependent urate hydroxylase HpxO	-
HZT23_RS12210 (2509001)	2509001..2509924	-	924	WP_186602016.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	blaOKP-B-5	mgtC / iroE / sciN/tssJ / tssG / tssF	2309691..2789036	479345

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49039.30 Da
• Isoelectric Point: 8.2542

>T167790 WP_032456033.1 NZ_CP058859:c2504791-2503469 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAYLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Nucleotide

• Length: 1323 bp

>T167790 NZ_CP075464:2070-2357 [Escherichia coli]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9940.38 Da
• Isoelectric Point: 7.1997

>AT167790 WP_004205921.1 NZ_CP058859:c2505057-2504791 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT167790 NZ_CP075464:1822-2073 [Escherichia coli]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2A5MFC9