Detailed information of TA system TA167780

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 318321..318907
• Replicon: chromosome
• Accession: NZ_CP058859
• Organism: Klebsiella quasipneumoniae strain STLEFF_28

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: HZT23_RS01465
• Protein ID: WP_002920800.1
• Coordinates: 318539..318907 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: HZT23_RS01460
• Protein ID: WP_040221757.1
• Coordinates: 318321..318542 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HZT23_RS01440 (314478)	314478..315404	+	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-
HZT23_RS01445 (315401)	315401..316678	+	1278	WP_205426381.1	high-affinity branched-chain amino acid ABC transporter permease LivM	-
HZT23_RS01450 (316675)	316675..317442	+	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
HZT23_RS01455 (317444)	317444..318157	+	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
HZT23_RS01460 (318321)	318321..318542	+	222	WP_040221757.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HZT23_RS01465 (318539)	318539..318907	+	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
HZT23_RS01470 (319256)	319256..320572	+	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
HZT23_RS01475 (320679)	320679..321566	+	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
HZT23_RS01480 (321563)	321563..322408	+	846	WP_004202115.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
HZT23_RS01485 (322410)	322410..323480	+	1071	WP_017899977.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	315401..324217	8816

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T167780 WP_002920800.1 NZ_CP058859:318539-318907 [Klebsiella quasipneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T167780 NZ_CP058859:318539-318907 [Klebsiella quasipneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
TGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8133.12 Da
• Isoelectric Point: 4.7769

>AT167780 WP_040221757.1 NZ_CP058859:318321-318542 [Klebsiella quasipneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARIDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT167780 NZ_CP058859:318321-318542 [Klebsiella quasipneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGACAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATAGATG
ATGAGTTCGCGGCAATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1