Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4899667..4900183 Replicon chromosome
Accession NZ_CP058857
Organism Klebsiella pneumoniae strain STLE2

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HZT19_RS24130 Protein ID WP_002886902.1
Coordinates 4899667..4899951 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HZT19_RS24135 Protein ID WP_002886901.1
Coordinates 4899941..4900183 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT19_RS24105 (HZT19_24040) 4895151..4895414 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
HZT19_RS24110 (HZT19_24045) 4895544..4895717 + 174 WP_002886906.1 hypothetical protein -
HZT19_RS24115 (HZT19_24050) 4895720..4896463 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HZT19_RS24120 (HZT19_24055) 4896820..4898958 + 2139 WP_042943710.1 anaerobic ribonucleoside-triphosphate reductase -
HZT19_RS24125 (HZT19_24060) 4899199..4899663 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HZT19_RS24130 (HZT19_24065) 4899667..4899951 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HZT19_RS24135 (HZT19_24070) 4899941..4900183 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HZT19_RS24140 (HZT19_24075) 4900261..4902171 - 1911 WP_004152270.1 PRD domain-containing protein -
HZT19_RS24145 (HZT19_24080) 4902194..4903348 - 1155 WP_002886900.1 lactonase family protein -
HZT19_RS24150 (HZT19_24085) 4903414..4904154 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T167776 WP_002886902.1 NZ_CP058857:c4899951-4899667 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T167776 NZ_CP075462:736020-736316 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT167776 WP_002886901.1 NZ_CP058857:c4900183-4899941 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT167776 NZ_CP075462:736318-736713 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCACAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References