Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4804381..4805216 | Replicon | chromosome |
| Accession | NZ_CP058857 | ||
| Organism | Klebsiella pneumoniae strain STLE2 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | HZT19_RS23740 | Protein ID | WP_001559913.1 |
| Coordinates | 4804381..4804758 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | HZT19_RS23745 | Protein ID | WP_032408847.1 |
| Coordinates | 4804848..4805216 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT19_RS23700 (HZT19_23635) | 4799842..4800516 | + | 675 | WP_004152211.1 | hypothetical protein | - |
| HZT19_RS23705 (HZT19_23640) | 4800528..4800866 | + | 339 | WP_064449948.1 | hypothetical protein | - |
| HZT19_RS23710 (HZT19_23645) | 4800869..4801348 | + | 480 | WP_002887049.1 | type VI secretion system tube protein TssD | - |
| HZT19_RS23715 (HZT19_23650) | 4801540..4801863 | - | 324 | Protein_4655 | hypothetical protein | - |
| HZT19_RS23720 (HZT19_23655) | 4801882..4802993 | - | 1112 | Protein_4656 | IS3 family transposase | - |
| HZT19_RS23725 (HZT19_23660) | 4803445..4803594 | - | 150 | Protein_4657 | restriction endonuclease subunit M | - |
| HZT19_RS23730 (HZT19_23665) | 4803679..4803876 | - | 198 | WP_032408848.1 | DUF957 domain-containing protein | - |
| HZT19_RS23735 (HZT19_23670) | 4803896..4804384 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| HZT19_RS23740 (HZT19_23675) | 4804381..4804758 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| HZT19_RS23745 (HZT19_23680) | 4804848..4805216 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HZT19_RS23750 (HZT19_23685) | 4805393..4805614 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| HZT19_RS23755 (HZT19_23690) | 4805683..4806159 | - | 477 | WP_032408846.1 | RadC family protein | - |
| HZT19_RS23760 (HZT19_23695) | 4806174..4806659 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| HZT19_RS23765 (HZT19_23700) | 4806751..4807569 | - | 819 | WP_001559911.1 | DUF932 domain-containing protein | - |
| HZT19_RS23770 (HZT19_23705) | 4807669..4807902 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| HZT19_RS23775 (HZT19_23710) | 4807981..4808436 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4800869..4823172 | 22303 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T167775 WP_001559913.1 NZ_CP058857:c4804758-4804381 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T167775 NZ_CP075462:672368-672682 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT167775 WP_032408847.1 NZ_CP058857:c4805216-4804848 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT167775 NZ_CP075462:672679-673095 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |