Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4159023..4159642 Replicon chromosome
Accession NZ_CP058857
Organism Klebsiella pneumoniae strain STLE2

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HZT19_RS20610 Protein ID WP_002892050.1
Coordinates 4159424..4159642 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HZT19_RS20605 Protein ID WP_002892066.1
Coordinates 4159023..4159397 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT19_RS20595 (HZT19_20540) 4154175..4155368 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HZT19_RS20600 (HZT19_20545) 4155391..4158537 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HZT19_RS20605 (HZT19_20550) 4159023..4159397 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HZT19_RS20610 (HZT19_20555) 4159424..4159642 + 219 WP_002892050.1 HHA domain-containing protein Toxin
HZT19_RS20615 (HZT19_20560) 4159801..4160367 + 567 WP_002892030.1 maltose O-acetyltransferase -
HZT19_RS20620 (HZT19_20565) 4160339..4160479 - 141 WP_004147370.1 hypothetical protein -
HZT19_RS20625 (HZT19_20570) 4160500..4160970 + 471 WP_002892026.1 YlaC family protein -
HZT19_RS20630 (HZT19_20575) 4160945..4162396 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HZT19_RS20635 (HZT19_20580) 4162497..4163195 + 699 WP_002892021.1 GNAT family protein -
HZT19_RS20640 (HZT19_20585) 4163192..4163332 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HZT19_RS20645 (HZT19_20590) 4163332..4163595 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T167773 WP_002892050.1 NZ_CP058857:4159424-4159642 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T167773 NZ_CP075462:205480-205587 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT167773 WP_002892066.1 NZ_CP058857:4159023-4159397 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT167773 NZ_CP075462:c205431-205368 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References