Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 937108..937765 Replicon chromosome
Accession NZ_CP058857
Organism Klebsiella pneumoniae strain STLE2

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HZT19_RS04770 Protein ID WP_002916310.1
Coordinates 937355..937765 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HZT19_RS04765 Protein ID WP_002916312.1
Coordinates 937108..937374 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZT19_RS04740 (HZT19_04740) 932264..933697 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HZT19_RS04745 (HZT19_04745) 933816..934544 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HZT19_RS04750 (HZT19_04750) 934594..934905 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HZT19_RS04755 (HZT19_04755) 935069..935728 + 660 WP_002916317.1 hemolysin III family protein -
HZT19_RS04760 (HZT19_04760) 935879..936862 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HZT19_RS04765 (HZT19_04765) 937108..937374 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HZT19_RS04770 (HZT19_04770) 937355..937765 + 411 WP_002916310.1 protein YgfX Toxin
HZT19_RS04775 (HZT19_04775) 937772..938293 - 522 WP_002916308.1 flavodoxin FldB -
HZT19_RS04780 (HZT19_04780) 938394..939290 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HZT19_RS04785 (HZT19_04785) 939313..940026 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZT19_RS04790 (HZT19_04790) 940032..941765 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T167763 WP_002916310.1 NZ_CP058857:937355-937765 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T167763 NZ_CP075452:c4756474-4756190 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT167763 WP_002916312.1 NZ_CP058857:937108-937374 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT167763 NZ_CP075452:c4756706-4756464 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References