Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3649806..3650641 | Replicon | chromosome |
| Accession | NZ_CP058853 | ||
| Organism | Shigella flexneri strain STLEFF_38 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | HZT29_RS17625 | Protein ID | WP_000854821.1 |
| Coordinates | 3650264..3650641 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HZT29_RS17620 | Protein ID | WP_032216526.1 |
| Coordinates | 3649806..3650174 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HZT29_RS17580 (3644929) | 3644929..3645813 | + | 885 | WP_240764963.1 | 50S ribosome-binding GTPase | - |
| HZT29_RS17585 (3645932) | 3645932..3646609 | + | 678 | WP_001097364.1 | hypothetical protein | - |
| HZT29_RS17590 (3646615) | 3646615..3646848 | + | 234 | WP_001278282.1 | DUF905 family protein | - |
| HZT29_RS17595 (3646947) | 3646947..3647765 | + | 819 | WP_053902307.1 | DUF932 domain-containing protein | - |
| HZT29_RS17600 (3647857) | 3647857..3648342 | + | 486 | WP_032216512.1 | antirestriction protein | - |
| HZT29_RS17605 (3648358) | 3648358..3648834 | + | 477 | WP_001186724.1 | RadC family protein | - |
| HZT29_RS17610 (3648903) | 3648903..3649124 | + | 222 | WP_001601167.1 | DUF987 domain-containing protein | - |
| HZT29_RS17615 (3649143) | 3649143..3649787 | + | 645 | Protein_3448 | antitoxin of toxin-antitoxin stability system | - |
| HZT29_RS17620 (3649806) | 3649806..3650174 | + | 369 | WP_032216526.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HZT29_RS17625 (3650264) | 3650264..3650641 | + | 378 | WP_000854821.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| HZT29_RS17630 (3650638) | 3650638..3650787 | + | 150 | Protein_3451 | DUF5983 family protein | - |
| HZT29_RS17635 (3650863) | 3650863..3651060 | + | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| HZT29_RS17640 (3651145) | 3651145..3651987 | + | 843 | WP_001529559.1 | DUF4942 domain-containing protein | - |
| HZT29_RS17645 (3652268) | 3652268..3652804 | - | 537 | WP_000942792.1 | GspM family type II secretion system protein YghD | - |
| HZT29_RS17650 (3652806) | 3652806..3653984 | - | 1179 | WP_000094976.1 | type II secretion system protein GspL | - |
| HZT29_RS17655 (3653981) | 3653981..3654958 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| HZT29_RS17660 (3654955) | 3654955..3655560 | - | 606 | WP_001514540.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T167754 WP_000854821.1 NZ_CP058853:3650264-3650641 [Shigella flexneri]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T167754 NZ_CP075452:353358-353705 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGACGATTACTATGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13810.69 Da Isoelectric Point: 6.2066
>AT167754 WP_032216526.1 NZ_CP058853:3649806-3650174 [Shigella flexneri]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT167754 NZ_CP075452:353705-354004 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|